[Heart in sepsis : Molecular mechanisms, diagnosis and therapy of septic cardiomyopathy].
Sign Up to like & getrecommendations! Published in 2017 at "Der Anaesthesist"
DOI: 10.1007/s00101-017-0329-x
Abstract: An impairment of cardiac function is a key feature of cardiovascular failure associated with sepsis; however, its clinical relevance is still underestimated. Recent advancements in echocardiography in patients with septic shock enable a better characterization of… read more here.
Keywords: sepsis molecular; heart sepsis; septic cardiomyopathy; diagnosis ... See more keywords
Septic Cardiomyopathy: From Basics to Management Choices.
Sign Up to like & getrecommendations! Published in 2020 at "Current problems in cardiology"
DOI: 10.1016/j.cpcardiol.2020.100767
Abstract: Septic cardiomyopathy (SCM) is increasingly recognized as a potential complication of septic shock; it is understood to be a reversible left ventricular systolic dysfunction. The presence of SCM in septic shock, in previous studies, infer… read more here.
Keywords: management choices; septic shock; management; basics management ... See more keywords
α2A-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23304-7
Abstract: Cardiomyopathy is a common complication associated with increased mortality in sepsis, but lacks specific therapy. Here, using genetic and pharmacological approaches, we explored the therapeutic effect of α2A-adrenergic receptor (AR) blockade on septic cardiomyopathy. CLP-induced… read more here.
Keywords: cardiac endothelial; norepinephrine concentration; blockade attenuates; cardiac norepinephrine ... See more keywords
Efficacy of Levosimendan in the Treatment of Patients With Severe Septic Cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiothoracic and vascular anesthesia"
DOI: 10.1053/j.jvca.2022.10.032
Abstract: OBJECTIVE This study was designed to compare the effects of levosimendan and dobutamine on hemodynamics and clinical efficacy in patients with severe septic cardiomyopathy (left ventricular ejection fraction [LVEF] ≤35%). DESIGN A prospective, single-blind, randomized… read more here.
Keywords: dobutamine; septic cardiomyopathy; patients severe; severe septic ... See more keywords
Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis*
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DOI: 10.1097/ccm.0000000000002207
Abstract: Objectives: The mechanism(s) for septic cardiomyopathy in humans is not known. To address this, we measured messenger RNA alterations in hearts from patients who died from systemic sepsis, in comparison to changed messenger RNA expression… read more here.
Keywords: heart; energy production; septic cardiomyopathy; messenger rna ... See more keywords
Septic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000002851
Abstract: Objectives: To describe, with an emphasis on clinical applications, what is known about the pathophysiology, management, and implications of septic cardiomyopathy in the adult ICU. Data Sources and Study Selection: A PubMed literature review was… read more here.
Keywords: sepsis; cardiomyopathy; septic cardiomyopathy;
Regulation of mammalian target of rapamycin on ferroptosis: from mechanism to therapeutics in septic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002301
Abstract: Sepsis refers to multiple organ dysfunction caused by the host ’ s dysfunctional response to infection. Most importantly, myocardial injury in septic patients, that is, septic cardiomyopathy (SIC), accounts for 1/3 to 1/2 of the… read more here.
Keywords: target rapamycin; septic cardiomyopathy; regulation mammalian; mammalian target ... See more keywords
Ketone Body β-Hydroxybutyrate Prevents Myocardial Oxidative Stress in Septic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2513837
Abstract: Septic cardiomyopathy is a life-threatening complication of severe sepsis and septic shock. Oxidative stress and mitochondrial dysfunction have been identified as significant abnormalities in septic cardiomyopathy. However, specific treatments are rare. This study aims to… read more here.
Keywords: septic cardiomyopathy; oxidative stress; myocardial oxidative; cardiomyopathy ... See more keywords
Syphilis-associated septic cardiomyopathy: case report and review of the literature
Sign Up to like & getrecommendations! Published in 2021 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-020-05722-z
Abstract: Background Septic cardiomyopathy has been observed in association with influenza, indicating that not only bacteria but also other infective agents can cause this condition. There has been no systematic study as to whether Treponema pallidum… read more here.
Keywords: syphilis associated; report; septic cardiomyopathy; associated septic ... See more keywords
Role of the lectin-like domain of thrombomodulin in septic cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.2139/ssrn.4051242
Abstract: AIMS Septic cardiomyopathy is a severe complication of sepsis and septic shock. This study aimed to evaluate the role of thrombomodulin and its lectin-like domain (LLD-TM) in the development of septic cardiomyopathy and the link… read more here.
Keywords: lectin like; septic cardiomyopathy; cardiac function; like domain ... See more keywords
Hydroxysafflor yellow A ameliorates Toll-like receptor 4-mediated septic cardiomyopathy.
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DOI: 10.2174/1567201819666220413130254
Abstract: BACKGROUND Sepsis is a life-threatening condition caused by bacterially-induced systemic inflammation that can result in septic cardiomyopathy. Bacterial lipopolysaccharide (LPS) stimulates the Toll-like receptor 4 (TLR4, Tlr4)-induced inflammatory response and intracellular reactive oxygen species (ROS)… read more here.
Keywords: md2; hsya; toll like; septic cardiomyopathy ... See more keywords