The role of TREM‐1 in septic myocardial pyroptosis and septic cardiomyopathy in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31445
Abstract: Septic cardiomyopathy (SCM) is an acute cardiac dysfunction involving myocardial cell pyroptosis. TREM‐1 is a known receptor on cell membrane that can amplify the inflammatory response. Our previous studies have shown that TREM‐1 in cardiomyocytes… read more here.
Keywords: pyroptosis; trem; role trem; septic cardiomyopathy ... See more keywords
[Heart in sepsis : Molecular mechanisms, diagnosis and therapy of septic cardiomyopathy].
Sign Up to like & getrecommendations! Published in 2017 at "Der Anaesthesist"
DOI: 10.1007/s00101-017-0329-x
Abstract: An impairment of cardiac function is a key feature of cardiovascular failure associated with sepsis; however, its clinical relevance is still underestimated. Recent advancements in echocardiography in patients with septic shock enable a better characterization of… read more here.
Keywords: sepsis molecular; heart sepsis; septic cardiomyopathy; diagnosis ... See more keywords
Targeting Lcn2 to Inhibit Myocardial Cell Ferroptosis is a Potential Therapy for Alleviating Septic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2025 at "Inflammation"
DOI: 10.1007/s10753-025-02250-3
Abstract: Septic cardiomyopathy (SCM) represents a key feature of sepsis-associated cardiovascular failure, and ferroptosis is one of the essential causes of septic cardiac dysfunction. In this study, combined with omics analysis and in vivo experiments, we… read more here.
Keywords: ferroptosis; septic cardiomyopathy; lcn2 inhibit; targeting lcn2 ... See more keywords
Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-024-10020-3
Abstract: Septic cardiomyopathy is a severe cardiovascular disease with a poor prognosis. Previous studies have reported the involvement of ferroptosis in the pathogenesis of septic cardiomyopathy. SGLT2 inhibitors such as dapagliflozin have been demonstrated to improve… read more here.
Keywords: attenuates lps; ferroptosis; injury; dapagliflozin attenuates ... See more keywords
Septic Cardiomyopathy: From Basics to Management Choices.
Sign Up to like & getrecommendations! Published in 2020 at "Current problems in cardiology"
DOI: 10.1016/j.cpcardiol.2020.100767
Abstract: Septic cardiomyopathy (SCM) is increasingly recognized as a potential complication of septic shock; it is understood to be a reversible left ventricular systolic dysfunction. The presence of SCM in septic shock, in previous studies, infer… read more here.
Keywords: management choices; septic shock; management; basics management ... See more keywords
α2A-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23304-7
Abstract: Cardiomyopathy is a common complication associated with increased mortality in sepsis, but lacks specific therapy. Here, using genetic and pharmacological approaches, we explored the therapeutic effect of α2A-adrenergic receptor (AR) blockade on septic cardiomyopathy. CLP-induced… read more here.
Keywords: cardiac endothelial; norepinephrine concentration; blockade attenuates; cardiac norepinephrine ... See more keywords
Efficacy of Levosimendan in the Treatment of Patients With Severe Septic Cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiothoracic and vascular anesthesia"
DOI: 10.1053/j.jvca.2022.10.032
Abstract: OBJECTIVE This study was designed to compare the effects of levosimendan and dobutamine on hemodynamics and clinical efficacy in patients with severe septic cardiomyopathy (left ventricular ejection fraction [LVEF] ≤35%). DESIGN A prospective, single-blind, randomized… read more here.
Keywords: dobutamine; septic cardiomyopathy; patients severe; severe septic ... See more keywords
Exploration and validation of signature genes and immune associations in septic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2024.2302570
Abstract: ABSTRACT An early and accurate diagnosis of septic cardiomyopathy is vital for improving the overall prognosis of sepsis. In our research, we aimed to identify signature genes and their immune connections in septic cardiomyopathy. By… read more here.
Keywords: exploration validation; septic cardiomyopathy; signature genes; genes immune ... See more keywords
HSPA12A impairs lipophagy to exaggerate septic cardiomyopathy by promoting MTOR's competition against LC3-II in binding with PNPLA2.
Sign Up to like & getrecommendations! Published in 2025 at "Autophagy"
DOI: 10.1080/15548627.2025.2600895
Abstract: Accumulation of lipid droplets (LDs) in cardiomyocytes contributes to developmentof septic cardiomyopathy, a fatal complication of critical illness in patients.Lipophagy is a selective autophagic mechanism for LD degradation. This processis inhibited by MTOR, but is… read more here.
Keywords: hspa12a; lc3; mtor; septic cardiomyopathy ... See more keywords
Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis*
Sign Up to like & getrecommendations! Published in 2017 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000002207
Abstract: Objectives: The mechanism(s) for septic cardiomyopathy in humans is not known. To address this, we measured messenger RNA alterations in hearts from patients who died from systemic sepsis, in comparison to changed messenger RNA expression… read more here.
Keywords: heart; energy production; septic cardiomyopathy; messenger rna ... See more keywords
Septic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000002851
Abstract: Objectives: To describe, with an emphasis on clinical applications, what is known about the pathophysiology, management, and implications of septic cardiomyopathy in the adult ICU. Data Sources and Study Selection: A PubMed literature review was… read more here.
Keywords: sepsis; cardiomyopathy; septic cardiomyopathy;