Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.05.038
Abstract: Sepsis-associated encephalopathy (SAE) manifested clinically in acute and long-term cognitive impairments and associated with increased morbidity and mortality worldwide. The potential pathological changes of SAE are complex and remain to be elucidated. Pyroptosis, a novel… read more here.
Keywords: sepsis; caspase; cognitive impairments; septic mice ... See more keywords
Infiltrated regulatory T cells and Th2 cells in the brain contribute to attenuation of sepsis-associated encephalopathy and alleviation of mental impairments in mice with polymicrobial sepsis
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.11.010
Abstract: Sepsis-associated encephalopathy (SAE) increases not only morbidity and mortality but has been associated with long-lasting mental impairment after hospital discharge in septic patients. Recently, studies have shown that these mental impairments are caused by infection-induced… read more here.
Keywords: sepsis; th2 cells; septic mice; mental impairments ... See more keywords
Down-regulated HDAC1 and up-regulated microRNA-124-5p recover myocardial damage of septic mice.
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2034583
Abstract: Studies have revealed the relationship between histone deacetylases (HDACs)/microRNAs (miRNAs) and sepsis, but little has ever investigated the mechanism of HDAC1/miR-124-5p in sepsis. Herein, we studied the impacts of HDAC1/miR-124-5p on myocardial damage of septic… read more here.
Keywords: expression; septic mice; mice; mir 124 ... See more keywords
1607: EFFECTS OF RECOMBINANT HUMAN THROMBOMODULIN ON NET FORMATION IN ORGANS OF SEPTIC MICE
Sign Up to like & getrecommendations! Published in 2019 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000552349.22349.cc
Abstract: Learning Objectives: Neutrophil extracellular traps (NETs) are important for local defense against invading pathogens. Excessive systemic NET formation, however, could induced coagulopathy, microcirculatory dysfunction, and organ damage. Consistent with this, NETs have been reported to… read more here.
Keywords: septic mice; formation; rtm group; thrombomodulin ... See more keywords
Murine Pancreatic Cancer Alters T Cell Activation and Apoptosis and Worsens Survival After Cecal Ligation and Puncture
Sign Up to like & getrecommendations! Published in 2019 at "SHOCK"
DOI: 10.1097/shk.0000000000001203
Abstract: ABSTRACT Patients with cancer who develop sepsis have a markedly higher mortality than patients who were healthy prior to the onset of sepsis. Potential mechanisms underlying this difference have previously been examined in two preclinical… read more here.
Keywords: sepsis; cancer; septic mice; apoptosis ... See more keywords
KLF4 down‐regulation resulting from TLR4 promotion of ERK1/2 phosphorylation underpins inflammatory response in sepsis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16082
Abstract: Sepsis is a systemic inflammatory response to invading pathogens, leading to high mortality rates in intensive care units worldwide. Krüppel‐like factor 4 (KLF4) is an important anti‐inflammatory transcription factor. In this study, we investigate the… read more here.
Keywords: sepsis; klf4; septic mice; inflammatory response ... See more keywords
Lacticaseibacillus rhamnosus TR08 alleviated intestinal injury and modulated microbiota dysbiosis in septic mice
Sign Up to like & getrecommendations! Published in 2021 at "BMC Microbiology"
DOI: 10.1186/s12866-021-02317-9
Abstract: Background Probiotics are widely used in intestinal microbiota imbalance caused by sepsis, however, the protective mechanism is still unclear. This study aimed to explore protective effect of Lacticaseibacillus rhamnosus TR08 on intestinal injury in septic… read more here.
Keywords: septic mice; rhamnosus tr08; lacticaseibacillus rhamnosus; mice ... See more keywords
Estrogen protects against liver damage in sepsis through inhibiting oxidative stress mediated activation of pyroptosis signaling pathway
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DOI: 10.1371/journal.pone.0239659
Abstract: Sepsis was characterized by systemic inflammatory response and multisystem organ dysfunction, refering to the activation of inflammatory and oxidative stress pathways. Estrogen has been shown to have anti-inflammatory and antioxidant effects as well as extensive… read more here.
Keywords: sepsis; septic mice; liver damage; activation ... See more keywords
The role of lipoprotein-associated phospholipase A2 in acute kidney injury of septic mice.
Sign Up to like & getrecommendations! Published in 2020 at "Translational andrology and urology"
DOI: 10.21037/tau-20-1173
Abstract: Background This experiment aimed to investigate the role and mechanism of lipoprotein-associated phospholipase A2 (Lp-PLA2) in kidney injury in septic mice induced by cecal ligation and perforation (CLP). Methods Male BALB/c mice were randomly divided… read more here.
Keywords: septic mice; pla2; group; mice ... See more keywords
Electroacupuncture at ST36 (Zusanli) Prevents T-Cell Lymphopenia and Improves Survival in Septic Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s361466
Abstract: Purpose Sepsis is the main cause of death in intensive care unit. Maladaptive cytokine storm and T-cell lymphopenia are critical prognosis predictors of sepsis. Electroacupuncture (EA) is expected to be an effective intervention to prevent… read more here.
Keywords: cell lymphopenia; st36 zusanli; septic mice; mice ... See more keywords
FGF15 Protects Septic Mice by Inhibiting Inflammation and Modulating Treg Responses
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s387613
Abstract: Background Fibroblast growth factor 15 (FGF15) through its FGF-receptor (FGFR)-4 inhibits hepatic inflammation. The current study aimed at investigating whether FGF15 could inhibit septic inflammation and its compensative regulatory T cell (Treg) responses in a… read more here.
Keywords: inflammation; treg responses; septic mice; treatment ... See more keywords