Micafungin Population PK Analysis in Healthy and Septic Pigs: Can the Septic Porcine Model Predict the Micafungin PK in Septic Patients?
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DOI: 10.1007/s11095-021-03137-2
Abstract: OBJECTIVES To describe micafungin pharmacokinetic (PK) alterations of sepsis induced in piglets and to determine whether the porcine septic model is able to predict the PK of micafungin in septic patients at the plasma and… read more here.
Keywords: micafungin septic; porcine; micafungin; septic patients ... See more keywords
The reduced form of coagulation factor XI is associated with illness severity and coagulopathy in critically-ill septic patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-018-1797-9
Abstract: Coagulation Factor XI (FXI) contributes to the pathobiology of sepsis-associated thrombosis and is a target for new therapeutics. Through cleavage of disulfide bonds, FXI becomes reduced (rFXI), accelerating intrinsic coagulation cascade activation. The role of… read more here.
Keywords: sepsis; coagulation; rfxi; septic patients ... See more keywords
Activated Protein C has No Effect on Pulmonary Capillary Endothelial Function in Septic Patients with Acute Respiratory Distress Syndrome: Association of Endothelial Dysfunction with Mortality
Sign Up to like & getrecommendations! Published in 2018 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-018-0192-3
Abstract: IntroductionPulmonary capillary endothelium-bound (PCEB) angiotensin-converting enzyme (ACE) activity is a direct and quantifiable index of pulmonary endothelial function that decreases early in acute respiratory distress syndrome (ARDS) and correlates with its severity. Endothelial dysfunction is… read more here.
Keywords: endothelial function; dysfunction; septic patients; ace activity ... See more keywords
Aminoglycosides in Critically Ill Septic Patients With Acute Kidney Injury Receiving Intermittent Hemodialysis: A Multicenter, Observational Study.
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DOI: 10.1016/j.clinthera.2021.04.015
Abstract: PURPOSE Data on aminoglycoside stewardship in critically ill septic patients with acute kidney injury (AKI) needing intermittent hemodialysis (IH) are scarce. The first objective of the study was to evaluate whether aminoglycoside administration occurs before… read more here.
Keywords: kidney injury; patients acute; acute kidney; critically ill ... See more keywords
Early increases in serum FGF21 levels predict mortality of septic patients
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DOI: 10.1016/j.cyto.2018.05.020
Abstract: Background Potential prognostic biomarkers for patients with sepsis have yet to be identified. The present study evaluated the prognostic value of fibroblast growth factor 21 (FGF21) levels in patients with sepsis. Methods A total of… read more here.
Keywords: sepsis; fgf21 levels; mortality; septic patients ... See more keywords
Endothelial injury in COVID-19 and septic patients
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DOI: 10.1016/j.mvr.2021.104303
Abstract: Systemic inflammatory response, as observed in sepsis and severe COVID-19, may lead to endothelial damage. Therefore, we aim to compare the extent of endothelial injury and its relationship to inflammation in both diseases. We included… read more here.
Keywords: endothelial injury; group; injury; septic patients ... See more keywords
An increased chloride level in hypochloremia is associated with decreased mortality in patients with severe sepsis or septic shock
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DOI: 10.1038/s41598-017-16238-z
Abstract: Only a few observational studies investigated the association between hypochloremia and mortality in critically ill patients, and these studies included small number of septic patients. Also, no study has evaluated the effect of an increase… read more here.
Keywords: level; mortality; hypochloremia; septic patients ... See more keywords
The Value of Decreased Thyroid Hormone for Predicting Mortality in Adult Septic Patients: A Systematic Review and Meta-Analysis
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DOI: 10.1038/s41598-018-32543-7
Abstract: Decreased thyroid hormone (TH) has been considered as one of the potential predictors of mortality in sepsis. This study aimed to evaluate the prognostic impact of decreased TH on mortality in septic patients during intensive… read more here.
Keywords: mortality adult; mortality; adult septic; septic patients ... See more keywords
Gentamicin Administration in Dialysis Patients: Before or After Hemodialysis?
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DOI: 10.1097/ftd.0000000000001058
Abstract: BACKGROUND Gentamicin is used to treat severe infections and has a small therapeutic window. This study aimed to optimize the dosing strategy of gentamicin in intermittently hemodialyzed patients by simulating concentration/time profiles during pre- and… read more here.
Keywords: cmax auc24h; gentamicin administration; cmax; dialysis ... See more keywords
A novel heart rate variability based risk prediction model for septic patients presenting to the emergency department
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DOI: 10.1097/md.0000000000010866
Abstract: Abstract A quick, objective, non-invasive means of identifying high-risk septic patients in the emergency department (ED) can improve hospital outcomes through early, appropriate management. Heart rate variability (HRV) analysis has been correlated with mortality in… read more here.
Keywords: risk; patients presenting; emergency department; septic patients ... See more keywords
PCR-based diagnosis of respiratory virus in postsurgical septic patients: A preliminary study before SARS-CoV-2 pandemic
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DOI: 10.1097/md.0000000000029902
Abstract: Respiratory viruses are part of the normal microbiota of the respiratory tract, which sometimes cause infection with/without respiratory insufficiency and the need for hospital or ICU admission. The aim of this study is to determine… read more here.
Keywords: respiratory viruses; sars cov; septic patients; respiratory ... See more keywords