Circular RNA circ_0001105 protects the intestinal barrier of septic rats by inhibiting inflammation and oxidative damage and YAP1 expression.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144897
Abstract: The integrity of the intestinal barrier is critical for protecting the host against the intestinal lumen and pathogens. The roles of circRNAs in the intestinal barrier dysfunction in sepsis remained unclear. The present study aims… read more here.
Keywords: intestinal barrier; circ 0001105; oxidative damage; septic rats ... See more keywords
MicroRNA-375-3p in endothelial progenitor cells-derived extracellular vesicles relieves myocardial injury in septic rats via BRD4-mediated PI3K/AKT signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107740
Abstract: OBJECTIVE Sepsis can induce myocardial dysfunctions and endothelial progenitor cells (EPCs)-derived extracellular vesicles (EVs) can attenuate sepsis. Concerning to that, this article is intended to decode whether microRNA (miR)-375-3p in EPCs-EVs could affect myocardial injury… read more here.
Keywords: myocardial injury; mir 375; septic rats; epcs evs ... See more keywords
Levosimendan pretreatment improves survival of septic rats after partial hepatectomy and suppresses iNOS induction in cytokine-stimulated hepatocytes
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DOI: 10.1038/s41598-019-48792-z
Abstract: We evaluated the survival effects and biochemical profiles of levosimendan in septic rats after partial hepatectomy and investigated its effects in cultured hepatocytes. Thirty-two rats underwent 70% hepatectomy and were randomised equally into four groups,… read more here.
Keywords: partial hepatectomy; pretreatment improves; hepatectomy; levosimendan pretreatment ... See more keywords
Treatment with methotrexate carried in lipid core nanoparticles prevents the development of diastolic dysfunction in septic rats
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3631
Abstract: In the development of sepsis, besides the dysregulation of the immune system and disturbances of several vital organs, life-threatening cardiac dysfunction often occurs. Previously, we showed that non-protein nanoparticles that resemble the lipid structure of… read more here.
Keywords: treatment; dysfunction; lde mtx; septic rats ... See more keywords
Liver and Kidney Surgical Anatomy to Verify the Effect of miR-221 on Organ Damage in Septic Rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Healthcare Engineering"
DOI: 10.1155/2022/2814431
Abstract: Background Related studies have shown that miR-221 has the ability to promote inflammatory response. This experiment mainly discusses the effect of miR-221 on acute liver and kidney injury in septic rats. Method Thirty Sprague Dawley… read more here.
Keywords: septic rats; expression; group; mir 221 ... See more keywords
Alterations in the gut microbiome and metabolome profiles of septic rats treated with aminophylline
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-022-03280-3
Abstract: The treatment of sepsis remains a major challenge worldwide. Aminophylline has been shown to have anti-inflammatory effects; however, the role of aminophylline in sepsis, a disease characterized by immune dysregulation, is unknown. In this study,… read more here.
Keywords: group; alterations gut; microbiome metabolome; intestinal flora ... See more keywords
Protective effect of N-acetylcysteine on acute lung injury in septic rats by inhibiting inflammation, oxidation, and apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.65350.14384
Abstract: Objective(s): Acute lung injury (ALI) is a common comorbidity in patients with sepsis, and finding drugs that can effectively reduce its mortality is a hot spot in current research. The purpose of this study is… read more here.
Keywords: lung tissue; acute lung; apoptosis; septic rats ... See more keywords
Effect of rosiglitazone on myocardial injury in septic rats through NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202001_19945
Abstract: INTRODUCTION To explore the effect of rosiglitazone on myocardial injury in septic rats through the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. MATERIALS AND METHODS A total of 60 healthy adult female Sprague-Dawley… read more here.
Keywords: myocardial injury; group; septic rats; rosiglitazone ... See more keywords
Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats
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DOI: 10.3389/fcimb.2022.818391
Abstract: Background Neutrophil elastase (NE) is associated with sepsis occurrence and progression. We hypothesized that the NE inhibitor Sivelestat might modulate abnormal gut microbiota and metabolites during sepsis. Methods Sixty Sprague-Dawley (SD) rats were randomly divided… read more here.
Keywords: gut microbiome; inhibitor sivelestat; septic rats; sivelestat ... See more keywords
Proteomic and phosphorylated proteomic landscape of injured lung in juvenile septic rats with therapeutic application of umbilical cord mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1034821
Abstract: Acute lung injury (ALI) is the most common complication of sepsis. Intravenous injection of HUMSCs can regulate the level of circulating endothelial cytokines and alleviate lung injury in juvenile septic rats. In this study, we… read more here.
Keywords: juvenile septic; septic rats; lung; phosphorylation ... See more keywords
[Protective effect of forsythiaside A on acute lung injury in septic rats].
Sign Up to like & getrecommendations! Published in 2022 at "Zhonghua wei zhong bing ji jiu yi xue"
DOI: 10.3760/cma.j.cn121430-20210517-00725
Abstract: OBJECTIVE To observe the protective effect of forsythiaside A on acute lung injury (ALI) in septic rats. METHODS Male Sprague-Dawley (SD) rats were randomly divided into normal control group, sham operation group, sepsis model group,… read more here.
Keywords: operation; p65; septic rats; model group ... See more keywords