Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14725-y
Abstract: Metazoan complexity and life-style depend on the bioenergetic potential of mitochondria. However, higher aerobic activity and genetic drift impose strong mutation pressure and risk of irreversible fitness decline in mitochondrial (mt)DNA-encoded genes. Bilaterian mitochondria-encoded tRNA… read more here.
Keywords: mitochondrial trnas; relaxed sequence; sequence constraints; mutational freedom ... See more keywords
Phenotypes can be robust and evolvable if mutations have non-local effects on sequence constraints
Sign Up to like & getrecommendations! Published in 2018 at "Journal of The Royal Society Interface"
DOI: 10.1098/rsif.2017.0618
Abstract: The mapping between biological genotypes and phenotypes plays an important role in evolution, and understanding the properties of this mapping is crucial to determine the outcome of evolutionary processes. One of the most striking properties… read more here.
Keywords: non local; local effects; sequence constraints; positive correlation ... See more keywords