Effect of RNA sequence context and stereochemistry on G-quadruplex-RHAU53 interaction.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.09.045
Abstract: RNA G-quadruplex (rG4) structure and its association with rG4-binding proteins/peptides are important for its function. However, there is very limited study that investigates what factors are involved in rG4 that drive the rG4-protein/peptide interaction. Here… read more here.
Keywords: rg4; rna sequence; rhau53; effect rna ... See more keywords
Site-Specific Synthesis of N4-Acetylcytidine in RNA Reveals Physiological Duplex Stabilization.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c11985
Abstract: N4-Acetylcytidine (ac4C) is a post-transcriptional modification of RNA that is conserved across all domains of life. All characterized sites of ac4C in eukaryotic RNA occur in the central nucleotide of a 5'-CCG-3' consensus sequence. However,… read more here.
Keywords: sequence context; rna; sequence; synthesis ... See more keywords
A Bayesian Framework for Inferring the Influence of Sequence Context on Point Mutations
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DOI: 10.1093/molbev/msz248
Abstract: Abstract The probability of point mutations is expected to be highly influenced by the flanking nucleotides that surround them, known as the sequence context. This phenomenon may be mainly attributed to the enzyme that modifies… read more here.
Keywords: sequence contexts; sequencing data; point mutations; sequence context ... See more keywords
Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.70680
Abstract: The human proteome is replete with short linear motifs (SLiMs) of four to six residues that are critical for protein-protein interactions, yet the importance of the sequence surrounding such motifs is underexplored. We devised a… read more here.
Keywords: ena vasp; context; proline; sequence context ... See more keywords