Articles with "sequence crossover" as a keyword



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Effect of Roxadustat on the Pharmacokinetics of Simvastatin, Rosuvastatin, and Atorvastatin in Healthy Subjects: Results From 3 Phase 1, Open‐Label, 1‐Sequence, Crossover Studies

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Published in 2022 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1076

Abstract: Roxadustat inhibits breast cancer resistance protein and organic anion transporting polypeptide 1B1, which can affect coadministered statin concentrations. Three open‐label, 1‐sequence crossover phase 1 studies in healthy subjects were conducted to assess effects from steady‐state… read more here.

Keywords: roxadustat; label sequence; sequence crossover; atorvastatin ... See more keywords
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The Effects of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Volunteers: A Single-Sequence Crossover Study

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Published in 2019 at "American Journal of Cardiovascular Drugs"

DOI: 10.1007/s40256-019-00348-2

Abstract: BackgroundThis was an open-label, phase I, nonrandomized, single-sequence, crossover study to evaluate the effect of concomitant administration of multiple doses of clarithromycin on the single-dose exposure, safety, and tolerability of apixaban in healthy subjects.MethodsIn total,… read more here.

Keywords: sequence crossover; administration; single sequence; clarithromycin ... See more keywords