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   Articles with "sequence defined" as a keyword



EGFR Targeting and Shielding of pDNA Lipopolyplexes via Bivalent Attachment of a Sequence-Defined PEG Agent.

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recommendations! Published in 2018 at "Macromolecular bioscience"

DOI: 10.1002/mabi.201700203

Abstract: For successful nonviral gene delivery, cationic polymers are promising DNA carrier, which need to comprise several functionalities. The current work focuses on the postincorporation of epidermal growth factor receptor (EGFR) targeted PEGylation agents onto lipopolyplexes… read more here.

Keywords: sequence defined; agent; egfr targeting; sequence ... See more keywords

Precision Design of Sequence‐Defined Polyurethanes: Exploring Controlled Folding Through Computational Design

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recommendations! Published in 2024 at "Macromolecular Chemistry and Physics"

DOI: 10.1002/macp.202400223

Abstract: This study presents the exploration of sequence‐defined polyurethanes (PUs) as a new class of heteropolymers capable of precise conformational control. Utilizing molecular dynamics simulations, the folding behavior of polyurethane chains is investigated of varying lengths… read more here.

Keywords: chemistry; precision design; sequence defined; sequence ... See more keywords
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Recent Progress in the Design of Monodisperse, Sequence-Defined Macromolecules.

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recommendations! Published in 2017 at "Macromolecular rapid communications"

DOI: 10.1002/marc.201600711

Abstract: This review describes different synthetic strategies towards sequence-defined, monodisperse macromolecules, which are built up by iterative approaches and lead to linear non-natural polymer structures. The review is divided in three parts: solution phase-, solid phase-,… read more here.

Keywords: sequence defined; progress design; monodisperse sequence; recent progress ... See more keywords
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Ugi Reaction of Amino Acids: From Facile Synthesis of Polypeptoids to Sequence-Defined Macromolecules.

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recommendations! Published in 2020 at "Macromolecular rapid communications"

DOI: 10.1002/marc.202000515

Abstract: Polypeptoids have been prepared and researched for more than 20 years. However, the efficient generation of polypeptoids and sequence-defined polypeptoids faces many challenges and difficulties. The Ugi reaction of amino acids has recently been introduced… read more here.

Keywords: sequence defined; reaction amino; ugi reaction; amino acids ... See more keywords

Exploring Cyclic Sulfamidate Building Blocks for the Synthesis of Sequence-Defined Macromolecules.

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recommendations! Published in 2021 at "Macromolecular rapid communications"

DOI: 10.1002/marc.202100193

Abstract: The preparation of sequence-defined macromolecules using cyclic sulfamidates on solid-phase is outlined. The challenges surrounding an AB+CD approach are described with focus on understanding the formation of ring-opened side products when using amide coupling reagents.… read more here.

Keywords: sequence defined; defined macromolecules; cyclic sulfamidates; exploring cyclic ... See more keywords

Covalent Attachment and Detachment by Reactive DESI of Sequence-Coded Polymer Taggants.

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recommendations! Published in 2022 at "Macromolecular rapid communications"

DOI: 10.1002/marc.202200412

Abstract: The use of sequence-defined polymers is an interesting emerging solution for materials identification and traceability. Indeed, a very large amount of identification sequences can be created using a limited alphabet of coded monomers. However, in… read more here.

Keywords: attachment detachment; covalent attachment; sequence coded; sequence defined ... See more keywords

Efficient Solution‐Phase Synthesis of Sequence‐Defined Oligourethanes with Precise Chirality Control

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recommendations! Published in 2025 at "Macromolecular Rapid Communications"

DOI: 10.1002/marc.202500378

Abstract: Nature relies on precisely defined macromolecules for complex biochemical processes with exceptional specificity and efficiency. To replicate these properties in synthetic systems, chemists have developed sequence‐defined macromolecules—polymers with absolute control over monomer sequence and structure,… read more here.

Keywords: solution phase; control; sequence defined; sequence ... See more keywords

Macromolecular Engineering: From Precise Macromolecular Inks to 3D Printed Microstructures.

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recommendations! Published in 2023 at "Small"

DOI: 10.1002/smll.202300844

Abstract: Macromolecules with complex, defined structures exist in nature but rarely is this degree of control afforded in synthetic macromolecules. Sequence-defined approaches provide a solution for precise control of the primary macromolecular structure. Despite a growing… read more here.

Keywords: precise macromolecular; sequence defined; sequence; precise ... See more keywords

Reading and writing data by using self-immolative, sequence-defined oligourethanes

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recommendations! Published in 2021 at "Chem"

DOI: 10.1016/j.chempr.2021.05.012

Abstract: Synthesis of sequence-defined oligourethanes (i.e., writing) followed by chemical self-immolation can yield mass fragments detectable by standard liquid chromatography-mass spectrometry (LC/MS) instruments (i.e., reading). Expanding beyond the traditional binary approach of chemically distinct monomers as… read more here.

Keywords: defined oligourethanes; reading writing; writing data; sequence defined ... See more keywords

Data storage in sequence-defined macromolecules via multicomponent reactions

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recommendations! Published in 2018 at "European Polymer Journal"

DOI: 10.1016/j.eurpolymj.2018.04.038

Abstract: Abstract Sequence-defined and information coding macromolecules suitable for data storage materials were synthesized via a combination of two multicomponent reactions. Thus, a well-established protocol based on the Passerini reaction was combined for the first time… read more here.

Keywords: sequence defined; multicomponent reactions; data storage; information ... See more keywords

Sequence defined antibodies improve the detection of cadherin 2 (N-cadherin) during zebrafish development.

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recommendations! Published in 2018 at "New biotechnology"

DOI: 10.1016/j.nbt.2017.12.008

Abstract: Cadherin-2 plays a fundamental role during zebrafish CNS and heart morphogenesis. Profiling zCdh2 expression via antibody staining is essential to achieving better understanding of its role during zebrafish development. Generation of recombinant human antibodies to… read more here.

Keywords: sequence defined; zebrafish development; defined antibodies; sequence ... See more keywords