EGFR Targeting and Shielding of pDNA Lipopolyplexes via Bivalent Attachment of a Sequence-Defined PEG Agent.
Sign Up to like & getrecommendations! Published in 2018 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201700203
Abstract: For successful nonviral gene delivery, cationic polymers are promising DNA carrier, which need to comprise several functionalities. The current work focuses on the postincorporation of epidermal growth factor receptor (EGFR) targeted PEGylation agents onto lipopolyplexes… read more here.
Keywords: sequence defined; agent; egfr targeting; sequence ... See more keywords
Recent Progress in the Design of Monodisperse, Sequence-Defined Macromolecules.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular rapid communications"
DOI: 10.1002/marc.201600711
Abstract: This review describes different synthetic strategies towards sequence-defined, monodisperse macromolecules, which are built up by iterative approaches and lead to linear non-natural polymer structures. The review is divided in three parts: solution phase-, solid phase-,… read more here.
Keywords: sequence defined; progress design; monodisperse sequence; recent progress ... See more keywords
Ugi Reaction of Amino Acids: From Facile Synthesis of Polypeptoids to Sequence-Defined Macromolecules.
Sign Up to like & getrecommendations! Published in 2020 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202000515
Abstract: Polypeptoids have been prepared and researched for more than 20 years. However, the efficient generation of polypeptoids and sequence-defined polypeptoids faces many challenges and difficulties. The Ugi reaction of amino acids has recently been introduced… read more here.
Keywords: sequence defined; reaction amino; ugi reaction; amino acids ... See more keywords
Exploring Cyclic Sulfamidate Building Blocks for the Synthesis of Sequence-Defined Macromolecules.
Sign Up to like & getrecommendations! Published in 2021 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202100193
Abstract: The preparation of sequence-defined macromolecules using cyclic sulfamidates on solid-phase is outlined. The challenges surrounding an AB+CD approach are described with focus on understanding the formation of ring-opened side products when using amide coupling reagents.… read more here.
Keywords: sequence defined; defined macromolecules; cyclic sulfamidates; exploring cyclic ... See more keywords
Covalent Attachment and Detachment by Reactive DESI of Sequence-Coded Polymer Taggants.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200412
Abstract: The use of sequence-defined polymers is an interesting emerging solution for materials identification and traceability. Indeed, a very large amount of identification sequences can be created using a limited alphabet of coded monomers. However, in… read more here.
Keywords: attachment detachment; covalent attachment; sequence coded; sequence defined ... See more keywords
Macromolecular Engineering: From Precise Macromolecular Inks to 3D Printed Microstructures.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202300844
Abstract: Macromolecules with complex, defined structures exist in nature but rarely is this degree of control afforded in synthetic macromolecules. Sequence-defined approaches provide a solution for precise control of the primary macromolecular structure. Despite a growing… read more here.
Keywords: precise macromolecular; sequence defined; sequence; precise ... See more keywords
Reading and writing data by using self-immolative, sequence-defined oligourethanes
Sign Up to like & getrecommendations! Published in 2021 at "Chem"
DOI: 10.1016/j.chempr.2021.05.012
Abstract: Synthesis of sequence-defined oligourethanes (i.e., writing) followed by chemical self-immolation can yield mass fragments detectable by standard liquid chromatography-mass spectrometry (LC/MS) instruments (i.e., reading). Expanding beyond the traditional binary approach of chemically distinct monomers as… read more here.
Keywords: defined oligourethanes; reading writing; writing data; sequence defined ... See more keywords
Data storage in sequence-defined macromolecules via multicomponent reactions
Sign Up to like & getrecommendations! Published in 2018 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2018.04.038
Abstract: Abstract Sequence-defined and information coding macromolecules suitable for data storage materials were synthesized via a combination of two multicomponent reactions. Thus, a well-established protocol based on the Passerini reaction was combined for the first time… read more here.
Keywords: sequence defined; multicomponent reactions; data storage; information ... See more keywords
Sequence defined antibodies improve the detection of cadherin 2 (N-cadherin) during zebrafish development.
Sign Up to like & getrecommendations! Published in 2018 at "New biotechnology"
DOI: 10.1016/j.nbt.2017.12.008
Abstract: Cadherin-2 plays a fundamental role during zebrafish CNS and heart morphogenesis. Profiling zCdh2 expression via antibody staining is essential to achieving better understanding of its role during zebrafish development. Generation of recombinant human antibodies to… read more here.
Keywords: sequence defined; zebrafish development; defined antibodies; sequence ... See more keywords
Hierarchical Nanomaterials Assembled from Peptoids and Other Sequence-Defined Synthetic Polymers.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.1c00024
Abstract: In nature, the self-assembly of sequence-specific biopolymers into hierarchical structures plays an essential role in the construction of functional biomaterials. To develop synthetic materials that can mimic and surpass the function of these natural counterparts,… read more here.
Keywords: sequence defined; self assembly; defined synthetic; hierarchical nanomaterials ... See more keywords
Revealing the Organization of Catalytic Sequence-Defined Oligomers via Combined Molecular Dynamics Simulations and Network Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00101
Abstract: Similar to biological macromolecules such as DNA and proteins, the precise control over the monomer position in sequence-defined polymers is of paramount importance for tuning their structures and properties toward achieving specific functions. Here, we… read more here.
Keywords: dynamics simulations; sequence defined; oligomers via; molecular dynamics ... See more keywords