The impact of flanking sequence features on DNA CpG methylation
Sign Up to like & getrecommendations! Published in 2021 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2021.107480
Abstract: Epigenetics and DNA methylation play a pivotal role in many processes of the cell and we often observe that an aberrant methylation pattern characterizes pathologies. In this work we investigate the role that the flanking… read more here.
Keywords: methylation; features dna; impact flanking; flanking sequence ... See more keywords
Sequence features of variable region determining physicochemical properties and polyreactivity of therapeutic antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.06.012
Abstract: Therapeutic antibodies have transformed the clinical practice. Not surprisingly, development of antibody therapeutics is currently the main focus of the biotechnology industry. Nonetheless, the development process is complex, and many antibodies do not reach the… read more here.
Keywords: therapeutic antibodies; features variable; polyreactivity; variable region ... See more keywords
Comparative analysis of the relationship between translation efficiency and sequence features of endogenous proteins in multiple organisms.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.05.037
Abstract: The translation efficiency of protein genes is known to be affected by sequence features. Previous studies have found that various sequence features based on codon usage and mRNA secondary structure contribute to translation efficiency. However,… read more here.
Keywords: sequence features; sequence; translation efficiency; relationship translation ... See more keywords
Accurate prediction and key protein sequence feature identification of cyclins.
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elad014
Abstract: Cyclin proteins are a group of proteins that activate the cell cycle by forming complexes with cyclin-dependent kinases. Identifying cyclins correctly can provide key clues to understanding the function of cyclins. However, due to the… read more here.
Keywords: sequence features; protein sequence; cyclin; key protein ... See more keywords
Key sequence features of CRISPR RNA for dual-guide CRISPR-Cas9 ribonucleoprotein complexes assembled with wild-type or HiFi Cas9
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac100
Abstract: Abstract Specific sequence features of the protospacer and protospacer-adjacent motif (PAM) are critical for efficient cleavage by CRISPR-Cas9, but current knowledge is largely derived from single-guide RNA (sgRNA) systems assessed in cultured cells. In this… read more here.
Keywords: cas9; crispr cas9; sequence features; wild type ... See more keywords
ISGm1A: Integration of Sequence Features and Genomic Features to Improve the Prediction of Human m1A RNA Methylation Sites
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Access"
DOI: 10.1109/access.2020.2991070
Abstract: As a new epitranscriptomic modification, N1-methyladenosine (m1A) plays an important role in the gene expression regulation. Although some computational methods were proposed to predict m1A modification sites, all of these methods apply machine learning predictions… read more here.
Keywords: sequence features; m1a rna; m1a; prediction ... See more keywords
DNA sequence features in the establishing of H3K27ac
Sign Up to like & getrecommendations! Published in 2018 at "F1000Research"
DOI: 10.12688/f1000research.13441.2
Abstract: The presence of H3K27me3 has been demonstrated to correlate with the CpG content. In this work, we tested whether H3K27ac has similar sequence preferences. We performed a translocation of DNA sequences with various properties into… read more here.
Keywords: dna sequence; sequence; features establishing; sequence features ... See more keywords
T1SEstacker: A Tri-Layer Stacking Model Effectively Predicts Bacterial Type 1 Secreted Proteins Based on C-Terminal Non-repeats-in-Toxin-Motif Sequence Features
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.813094
Abstract: Type 1 secretion systems play important roles in pathogenicity of Gram-negative bacteria. However, the substrate secretion mechanism remains largely unknown. In this research, we observed the sequence features of repeats-in-toxin (RTX) proteins, a major class… read more here.
Keywords: type secreted; sequence features; sequence; stacking model ... See more keywords