Pathogenic Signal Sequence Mutations in Progranulin Disrupt SRP Interactions Required for mRNA Stability
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.05.003
Abstract: SUMMARY Cells have evolved quality control pathways to prevent the accumulation of improperly localized proteins, which are often toxic. One of these pathways, regulation of aberrant protein production (RAPP), recognizes aberrant secretory proteins during translation… read more here.
Keywords: progranulin disrupt; signal sequence; grn; sequence mutations ... See more keywords
Fine-mapping sequence mutations with a major effect on oligosaccharide content in bovine milk
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38488-9
Abstract: Human milk contains abundant oligosaccharides (OS) which are believed to have strong health benefits for neonates. OS are a minor component of bovine milk and little is known about how the production of OS is… read more here.
Keywords: milk; bovine milk; sequence mutations; mapping sequence ... See more keywords