Preferential self-interaction of DNA methyltransferase DNMT3A subunits containing the R882H cancer mutation leads to dominant changes of flanking sequence preferences.
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DOI: 10.1016/j.jmb.2022.167482
Abstract: Somatic R882H DNMT3A mutations occur frequently in AML, but their pathogenic mechanism is unclear. As R882H mutations usually are heterozygous, wildtype (WT) and R882H subunits co-exist in affected cells. R882 is located in the RD… read more here.
Keywords: containing r882h; flanking sequence; dnmt3a; sequence preferences ... See more keywords