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Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.01.014
Abstract: HighlightsSynesthesia and autism spectrum are evaluated within the family of an individual with autism spectrum and savant abilities.Superior prevalence of synesthesia and autism spectrum are observed.All members reported a specific type of synesthesia: sequence‐space synesthesia.Spatial…
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Keywords:
autism;
synesthesia;
sequence space;
family ... See more keywords
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Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.02.018
Abstract: Screening of enzyme mutants in monodisperse picoliter compartments, generated at kilohertz speed in microfluidic devices, is coming of age. After a decade of proof-of-principle experiments, workflows have emerged that combine existing microfluidic modules to assay…
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Keywords:
sequence space;
exploring sequence;
search functional;
space search ... See more keywords
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Published in 2019 at "ACS Central Science"
DOI: 10.1021/acscentsci.9b01112
Abstract: Currently, there are more than 216 million annotated protein sequences available in public databases, a number that doubles every 28 months, and just like the deep sea floor, only a minuscule portion of this territory…
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Keywords:
class;
family;
function;
sequence ... See more keywords
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Published in 2017 at "Nature Microbiology"
DOI: 10.1038/nmicrobiol.2017.88
Abstract: RNA viruses pose serious threats to human health. Their success relies on their capacity to generate genetic variability and, consequently, on their adaptive potential. We describe a strategy to attenuate RNA viruses by altering their…
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Keywords:
sequence space;
rna;
attenuation rna;
rna viruses ... See more keywords
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Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2068212
Abstract: ABSTRACT The human adaptive immune response enables the targeting of epitopes on pathogens with high specificity. Infection with a pathogen induces somatic hyper-mutation and B-cell selection processes that govern the shape and diversity of the…
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Keywords:
antibody sequence;
sequence space;
human antibody;
sequence ... See more keywords
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Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02921-22
Abstract: Flaviviruses are medically important arboviruses that threaten public health, but no approved treatments are currently available. Vaccines prevent flavivirus infection. ABSTRACT Recently, a new strategy for attenuating RNA viruses by redirecting their evolution in sequence…
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Keywords:
cqw1 ots;
attenuation;
sequence space;
flavivirus ... See more keywords
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Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001569
Abstract: The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex folding landscapes. It is also possible, at least in theory, for proteostasis mechanisms that…
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Keywords:
proteostasis;
proteostasis network;
sequence space;
space accessible ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27103353
Abstract: The accumulation of polyethylene terephthalate (PET) seriously harms the environment because of its high resistance to degradation. The recent discovery of the bacteria-secreted biodegradation enzyme, PETase, sheds light on PET recycling; however, the degradation efficiency…
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Keywords:
dynamics simulations;
sequence space;
molecular dynamics;
petase ... See more keywords