Synesthesia & autistic features in a large family: Evidence for spatial imagery as a common factor
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.01.014
Abstract: HighlightsSynesthesia and autism spectrum are evaluated within the family of an individual with autism spectrum and savant abilities.Superior prevalence of synesthesia and autism spectrum are observed.All members reported a specific type of synesthesia: sequence‐space synesthesia.Spatial… read more here.
Keywords: autism; synesthesia; sequence space; family ... See more keywords
Exploring sequence space in search of functional enzymes using microfluidic droplets.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.02.018
Abstract: Screening of enzyme mutants in monodisperse picoliter compartments, generated at kilohertz speed in microfluidic devices, is coming of age. After a decade of proof-of-principle experiments, workflows have emerged that combine existing microfluidic modules to assay… read more here.
Keywords: sequence space; exploring sequence; search functional; space search ... See more keywords
Frontiers in Biocatalysis: Profiling Function across Sequence Space
Sign Up to like & getrecommendations! Published in 2019 at "ACS Central Science"
DOI: 10.1021/acscentsci.9b01112
Abstract: Currently, there are more than 216 million annotated protein sequences available in public databases, a number that doubles every 28 months, and just like the deep sea floor, only a minuscule portion of this territory… read more here.
Keywords: class; family; function; sequence ... See more keywords
Attenuation of RNA viruses by redirecting their evolution in sequence space
Sign Up to like & getrecommendations! Published in 2017 at "Nature Microbiology"
DOI: 10.1038/nmicrobiol.2017.88
Abstract: RNA viruses pose serious threats to human health. Their success relies on their capacity to generate genetic variability and, consequently, on their adaptive potential. We describe a strategy to attenuate RNA viruses by altering their… read more here.
Keywords: sequence space; rna; attenuation rna; rna viruses ... See more keywords
The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2068212
Abstract: ABSTRACT The human adaptive immune response enables the targeting of epitopes on pathogens with high specificity. Infection with a pathogen induces somatic hyper-mutation and B-cell selection processes that govern the shape and diversity of the… read more here.
Keywords: antibody sequence; sequence space; human antibody; sequence ... See more keywords
Single-molecule structural and kinetic studies across sequence space
Sign Up to like & getrecommendations! Published in 2024 at "Science"
DOI: 10.1126/science.adn5968
Abstract: At the core of molecular biology lies the intricate interplay between sequence, structure, and function. Single-molecule techniques provide in-depth dynamic insights into structure and function, but laborious assays impede functional screening of large sequence libraries.… read more here.
Keywords: sparxs; sequence; sequence space; single molecule ... See more keywords
Attenuation of Avian Flavivirus by Rewiring the Leucine and Serine Codons of Its E-NS1 Protein toward Stop Mutation To Redirect Virus Evolution
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02921-22
Abstract: Flaviviruses are medically important arboviruses that threaten public health, but no approved treatments are currently available. Vaccines prevent flavivirus infection. ABSTRACT Recently, a new strategy for attenuating RNA viruses by redirecting their evolution in sequence… read more here.
Keywords: cqw1 ots; attenuation; sequence space; flavivirus ... See more keywords
Exploring the energetic and conformational properties of the sequence space connecting naturally occurring RNA tetraloop receptor motifs
Sign Up to like & getrecommendations! Published in 2024 at "RNA"
DOI: 10.1261/rna.080039.124
Abstract: Folded RNAs contain tertiary contact motifs whose structures and energetics are conserved across different RNAs. The transferable properties of RNA motifs simplify the RNA folding problem, but measuring energetic and conformational properties of many motifs… read more here.
Keywords: tetraloop receptor; naturally occurring; conformational properties; sequence space ... See more keywords
The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001569
Abstract: The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex folding landscapes. It is also possible, at least in theory, for proteostasis mechanisms that… read more here.
Keywords: proteostasis; proteostasis network; sequence space; space accessible ... See more keywords
In Silico Identification of Potential Sites for a Plastic-Degrading Enzyme by a Reverse Screening through the Protein Sequence Space and Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27103353
Abstract: The accumulation of polyethylene terephthalate (PET) seriously harms the environment because of its high resistance to degradation. The recent discovery of the bacteria-secreted biodegradation enzyme, PETase, sheds light on PET recycling; however, the degradation efficiency… read more here.
Keywords: dynamics simulations; sequence space; molecular dynamics; petase ... See more keywords