Differentiating between the sequence of structural events on alternative pathways of folding of a heterodimeric protein
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4513
Abstract: Distinguishing between competing pathways of folding of a protein, on the basis of how they differ in their progress of structure acquisition, remains an important challenge in protein folding studies. A previous study had shown… read more here.
Keywords: heterodimeric protein; structure; sequence structural; alternative pathways ... See more keywords
Sequence and structural analysis of COVID-19 E and M proteins with MERS virus E and M proteins—A comparative study
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101023
Abstract: The outbreak of SARS in 2003, MERS in 2012, and now COVID-19 in 2019 have demonstrated that Coronaviruses are capable of causing primary lethal infections in humans, and the pandemic is now a global concern.… read more here.
Keywords: protein; sequence structural; analysis; mers virus ... See more keywords
Understanding the sequence and structural context effects in oxidative DNA damage repair.
Sign Up to like & getrecommendations! Published in 2020 at "DNA repair"
DOI: 10.1016/j.dnarep.2020.102906
Abstract: 8-Oxo-7,8-dihydroguanine (8-oxoG) is the major base damage in the genomic DNA by exposure to reactive oxygen species. Organisms have evolved various DNA repair mechanisms, such as base excision repair (BER) and nucleotide excision repair (NER),… read more here.
Keywords: dna damage; sequence structural; damage repair; oxidative dna ... See more keywords
The sequence, structural, and functional diversity within a protein family and implications for specificity and safety: The case for ETX_MTX2 insecticidal proteins.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of invertebrate pathology"
DOI: 10.1016/j.jip.2016.05.007
Abstract: The need for sustainable insect pest control is driving the investigation and discovery of insecticidal proteins outside of the typical 3-domain Cry protein family from Bacillus thuringiensis (Bt). Examples include Cry35 and Cry51 that belong… read more here.
Keywords: etx mtx2; sequence structural; safety; insecticidal proteins ... See more keywords
Dissecting the sequence and structural determinants guiding m6A deposition and evolution via inter- and intra-species hybrids
Sign Up to like & getrecommendations! Published in 2024 at "Genome Biology"
DOI: 10.1186/s13059-024-03182-1
Abstract: N6-methyladenosine (m6A) is the most abundant mRNA modification, and controls mRNA stability. m6A distribution varies considerably between and within species. Yet, it is unclear to what extent this variability is driven by changes in genetic… read more here.
Keywords: evolution; m6a; dissecting sequence; sequence structural ... See more keywords
Sequence and structural insights of monoleucine-based sorting motifs contained within the cytoplasmic domains of basolateral proteins
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2024.1379224
Abstract: Delivery to the correct membrane domain in polarized epithelial cells is a critical regulatory mechanism for transmembrane proteins. The trafficking of these proteins is directed by short amino acid sequences known as sorting motifs. In… read more here.
Keywords: sequence structural; sorting motifs; sorting motif; based sorting ... See more keywords