A novel model for tracking copolymerization kinetics: Sequence structure quality evaluation
Sign Up to like & getrecommendations! Published in 2024 at "AIChE Journal"
DOI: 10.1002/aic.18586
Abstract: Precise control over sequence structure in copolymers is essential for chemical product engineering. The complexity of sequence structures results in the challenging characterization of monomer sequences. Herein, a chemical composition model (CD model) is developed… read more here.
Keywords: structure; sequence; model; structure quality ... See more keywords
Advanced Protein Alignments Based on Sequence, Structure and Hydropathy Profiles; The Paradigm of the Viral Polymerase Enzyme
Sign Up to like & getrecommendations! Published in 2017 at "Mathematics in Computer Science"
DOI: 10.1007/s11786-016-0287-8
Abstract: One of the major drawbacks of modern bioinformatics is the fact that protein similarity and blast searches are still based on primary amino acid sequence rather than structural data. Primary sequence searches are inadequate, as… read more here.
Keywords: protein; alignments based; sequence structure; hydropathy ... See more keywords
Sequence and structure-based peptides as potent amyloid inhibitors: A review.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108614
Abstract: Misfolded and natively disordered globular proteins tend to aggregate together in an interwoven fashion to form fibrous, proteinaceous deposits referred to as amyloid fibrils. Formation and deposition of such insoluble fibrils are the characteristic features… read more here.
Keywords: peptides potent; structure based; sequence structure; structure ... See more keywords
18S rRNA gene sequence-structure phylogeny of the Trypanosomatida (Kinetoplastea, Euglenozoa) with special reference to Trypanosoma.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of protistology"
DOI: 10.1016/j.ejop.2021.125824
Abstract: Parasites of the order Trypanosomatida are known due to their medical relevance. Despite the progress made in the past decades on understanding the evolution of this group of organisms, there are still many open questions… read more here.
Keywords: 18s rrna; sequence structure; rrna gene;
Sequence- and structure-based computational analyses of Gram-negative tripartite efflux pumps in the context of bacterial membranes.
Sign Up to like & getrecommendations! Published in 2018 at "Research in microbiology"
DOI: 10.1016/j.resmic.2018.01.002
Abstract: Gram-negative multidrug resistance currently presents a serious threat to public health with infections effectively rendered untreatable. Multiple molecular mechanisms exist that cause antibiotic resistance and in addition, the last three decades have seen slowing rates… read more here.
Keywords: gram negative; negative tripartite; resistance; sequence structure ... See more keywords
Sequence-Structure Combination Strategy Enables Discovery of a Novel Transglutaminase from Krasilnikovia cinnamomea and Computational Analysis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c07950
Abstract: Transglutaminase (TGase) is a widely utilized biocatalyst in the food industry, where it catalyzes the cross-linking of proteins in protein-rich foods, leading to improved texture and enhanced functional properties. Currently, commercially available TGases are derived… read more here.
Keywords: tgase; transglutaminase; sequence structure; krasilnikovia cinnamomea ... See more keywords
Highly Similar Sequence and Structure Yet Different Biophysical Behavior: A Computational Study of Two Triosephosphate Isomerases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c01501
Abstract: Homodimeric triosephosphate isomerases (TIMs) from Trypanosoma cruzi (TcTIM) and Trypanosoma brucei (TbTIM) have markedly similar amino-acid sequences and three-dimensional structures. However, several of their biophysical parameters, such as their susceptibility to sulfhydryl agents and their… read more here.
Keywords: highly similar; sequence structure; triosephosphate isomerases; triosephosphate ... See more keywords
Insights of Life Molecules' Dynamic Distribution in Live Cells via Sequence-Structure Bispecific Fluorescent RNA.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c03626
Abstract: Life molecules' distributions in live systems construct the complex dynamic reaction networks, whereas it is still challenging to demonstrate the dynamic distributions of biomolecules in live systems. Herein, we proposed a dynamic analysis strategy via… read more here.
Keywords: structure; rna; life molecules; structure bispecific ... See more keywords
SSEmb: A joint embedding of protein sequence and structure enables robust variant effect predictions
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-53982-z
Abstract: The ability to predict how amino acid changes affect proteins has a wide range of applications including in disease variant classification and protein engineering. Many existing methods focus on learning from patterns found in either… read more here.
Keywords: structure; sequence; variant effect; sequence structure ... See more keywords
Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-06023-w
Abstract: Tetracycline destructases (TDases) are flavin monooxygenases which can confer resistance to all generations of tetracycline antibiotics. The recent increase in the number and diversity of reported TDase sequences enables a deep investigation of the TDase… read more here.
Keywords: resistance; structure function; structure; function ... See more keywords
Structural facets of POU2F1 in light of the functional annotations and sequence-structure patterns
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1733092
Abstract: Abstract POU domain class 2 homebox 1 or POU2F1 is broadly known as an important transcription factor. Due to its association with different types of malignancies, POU2F1 became one of the key factors in pancancer… read more here.
Keywords: structural facets; facets pou2f1; sequence structure; structure ... See more keywords