Long‐read sequencing for molecular diagnostics in constitutional genetic disorders
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24465
Abstract: Long‐read sequencing (LRS) has been around for more than a decade, but widespread adoption of the technology has been slow due to the perceived high error rates and high sequencing cost. This is changing due… read more here.
Keywords: diagnostics constitutional; sequencing molecular; lrs; read sequencing ... See more keywords
Genome sequencing and molecular characterisation of XDR Acinetobacter baumannii reveal complexities in resistance: Novel combination of sulbactam-durlobactam holds promise for therapeutic intervention.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30156
Abstract: Emerging nosocomial strains of Acinetobacter baumannii are of recent concern as they are expressing extensive drug resistance (XDR). Using whole-genome sequencing and molecular characterisation analysis, the current study reveals the presence of carbapenemase genes in… read more here.
Keywords: genome sequencing; kcal mol; resistance; sequencing molecular ... See more keywords
Next Generation Sequencing and Molecular Biomarkers in Ovarian Cancer—An Opportunity for Targeted Therapy
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DOI: 10.3390/diagnostics12040842
Abstract: Ovarian cancer is the deadliest of all gynecologic malignancies claiming the lives of nearly 14,000 women in the United States annually. Despite therapeutic advances, the ovarian cancer mortality rate has remained stagnant since the 1980’s.… read more here.
Keywords: sequencing molecular; ovarian cancer; next generation; cancer ... See more keywords
Next-generation sequencing and molecular therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical medicine"
DOI: 10.7861/clinmed.2022-0514
Abstract: Cancers contain a plethora of mutations, few of which are critical to maintaining a state of malignancy. With our ever-expanding understanding of the genomic complexity of cancer, potentially actionable biomarkers whose inhibition could cripple cancer… read more here.
Keywords: sequencing molecular; next generation; medicine; cancer ... See more keywords