Sign Up to like & get
recommendations!
0
Published in 2020 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22351
Abstract: Complex human diseases are affected by genetic and environmental risk factors and their interactions. Gene–environment interaction (GEI) tests for aggregate genetic variant sets have been developed in recent years. However, existing statistical methods become rate…
read more here.
Keywords:
scale sequencing;
sequencing studies;
gene environment;
environment interaction ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1457-z
Abstract: Exome-sequencing studies have generally been underpowered to identify deleterious alleles with a large effect on complex traits as such alleles are mostly rare. Because the population of northern and eastern Finland has expanded considerably and…
read more here.
Keywords:
deleterious alleles;
exome sequencing;
sequencing studies;
association power ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2018 at "Nature Genetics"
DOI: 10.1038/s41588-018-0113-0
Abstract: The triplet code underpins analyses of rare and de novo mutations in exome sequencing data, but analysis of the noncoding genome is much more challenging. A new analytical framework for common, complex diseases highlights the…
read more here.
Keywords:
studies common;
whole genome;
common diseases;
sizing whole ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008490
Abstract: Despite genetics being accepted as the primary cause of familial aggregation for most diseases, it is still unclear whether afflicted families are likely to share a single highly penetrant rare variant, many minimally penetrant common…
read more here.
Keywords:
prs;
familial aggregation;
genetics;
sequencing studies ... See more keywords