Phosphine-Mediated Sequential [2+4]/[2+3] Annulation to Construct Pyrroloquinolines.
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DOI: 10.1021/acs.orglett.1c04388
Abstract: A domino [2+4]/[2+3] sequential annulation reaction of MBH carbonates with N-unprotected indoles has been developed to provide various pyrroloquinoline derivatives in ≤94% yield and 20:1 dr. The reaction could be either mediated by stoichiometric PCy3… read more here.
Keywords: annulation construct; sequential annulation; mediated sequential; annulation ... See more keywords
Phosphine-Catalyzed Sequential [3 + 2]/[3 + 2] Annulation between Allenoates and Arylidenemalononitriles for the Enantioselective Construction of Bicyclo[3,3,0]octenes and Cyclopenta[c]quinolinones.
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DOI: 10.1021/acs.orglett.2c01352
Abstract: A highly diastereo- and enantioselective phosphine-catalyzed sequential [3 + 2]/[3 + 2] annulation of allenoates with arylidenemalononitriles has been developed. This reaction allows for the facile construction of multifunctionalized cis-fused bicyclic[3,3,0]octene scaffolds, encompassing three consecutive… read more here.
Keywords: phosphine catalyzed; catalyzed sequential; sequential annulation; annulation allenoates ... See more keywords