Group sequential design for randomized trials using “first hitting time” model
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DOI: 10.1002/sim.9360
Abstract: Group sequential design (GSD) has become a popular choice in recent clinical trials as it improves trial efficiency by providing options for early termination. The implementation of traditional tests for survival analysis (eg, the log‐rank… read more here.
Keywords: sequential design; first hitting; design; model ... See more keywords
Sequential design of an injection molding process using a calibrated predictor
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DOI: 10.1080/00224065.2018.1474696
Abstract: ABSTRACT This article optimizes an injection molding process using an efficient sequential design methodology. The goal is to set the process control variables to minimize the shrinkages of a selected collection of injection molded parts.… read more here.
Keywords: molding process; process; injection molding; sequential design ... See more keywords
A Bayesian sequential design using alpha spending function to control type I error
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DOI: 10.1177/0962280215595058
Abstract: We propose in this article a Bayesian sequential design using alpha spending functions to control the overall type I error in phase III clinical trials. We provide algorithms to calculate critical values, power, and sample… read more here.
Keywords: bayesian sequential; sequential design; alpha spending; power ... See more keywords