Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202507178
Abstract: Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM). Improving nucleus pulposus cells (NPCs) condition first requires a supportive surrounding environment. However, how to provide an… read more here.
Keywords: disc degeneration; sequential drug; nucleus pulposus; drug delivery ... See more keywords
Fine-tuning the sequential drug release of nano-formulated mutual prodrugs dictates the combination effects
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc00550j
Abstract: The maintenance of robust ratiometric loading of dual therapeutic agents and fine-tuning release kinetics for consistent in vitro and in vivo optimization of combination effects is vital for discovering new anticancer drug combinations and remains… read more here.
Keywords: sequential drug; combination effects; drug release; release ... See more keywords
Sequential Drug Delivery in Targeted Cancer Therapy
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DOI: 10.3390/pharmaceutics14030573
Abstract: Cancer is a major public health problem and one of the leading causes of death. However, traditional cancer therapy may damage normal cells and cause side effects. Many targeted drug delivery platforms have been developed… read more here.
Keywords: sequential drug; drug delivery; cancer therapy; drug ... See more keywords