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Published in 2018 at "Computational and Applied Mathematics"
DOI: 10.1007/s40314-018-0702-7
Abstract: Within the context of sequential methods for solving general nonlinear programming problems, and on the grounds of a previous work of the same authors, this study deals with the theoretical reasoning behind handling the original…
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Keywords:
augmented subproblems;
approximate solutions;
subproblems within;
solutions augmented ... See more keywords
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Published in 2018 at "Biometrics"
DOI: 10.1111/biom.13007
Abstract: This article takes a fresh look at group sequential methods applied to two-sample tests of censored survival data and proposes an alternative method of defining and evaluating treatment benefit. Our method re-purposes traditional censored event…
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Keywords:
benefit;
group;
group sequential;
follow windows ... See more keywords
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Published in 2022 at "Statistical Methods in Medical Research"
DOI: 10.1177/09622802221107103
Abstract: Late phase clinical trials are occasionally planned with one or more interim analyses to allow for early termination or adaptation of the study. While extensive theory has been developed for the analysis of ordered categorical…
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Keywords:
methods mann;
mann whitney;
whitney parameter;
sequential methods ... See more keywords