Bayesian methods to compare dose levels with placebo in a small n, sequential, multiple assignment, randomized trial.
Sign Up to like & getrecommendations! Published in 2020 at "Statistics in medicine"
DOI: 10.1002/sim.8813
Abstract: Clinical trials studying treatments for rare diseases are challenging to design and conduct due to the limited number of patients eligible for the trial. One design used to address this challenge is the small n,… read more here.
Keywords: trial; multiple assignment; small sequential; treatment ... See more keywords
Undertaking Experiments in Social Sciences: Sequential, Multiple Time Series Designs for Consideration
Sign Up to like & getrecommendations! Published in 2017 at "Educational Psychology Review"
DOI: 10.1007/s10648-016-9368-0
Abstract: In social sciences, the use of stringent methodological approaches is gaining increasing emphasis. Researchers have recognized the limitations of cross-sectional, non-manipulative data in the study of causality. True experimental designs, in contrast, are preferred as… read more here.
Keywords: time series; time; experimental designs; sequential multiple ... See more keywords
Optimizing delivery of a behavioral pain intervention in cancer patients using a sequential multiple assignment randomized trial SMART.
Sign Up to like & getrecommendations! Published in 2017 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2017.04.001
Abstract: BACKGROUND/AIMS Pain is common in cancer patients and results in lower quality of life, depression, poor physical functioning, financial difficulty, and decreased survival time. Behavioral pain interventions are effective and nonpharmacologic. Traditional randomized controlled trials… read more here.
Keywords: intervention; behavioral pain; cancer patients; sequential multiple ... See more keywords
Study protocol for a sequential multiple assignment randomized trial (SMART) to improve physical activity in employed women.
Sign Up to like & getrecommendations! Published in 2019 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2019.105921
Abstract: INTRODUCTION Physical activity monitors, motivational text messages, group meetings and personal calls have proven to be efficacious physical activity interventions. However, individual participant response to these interventions varies drastically. A SMART design (sequential multiple assignment… read more here.
Keywords: employed women; physical activity; activity monitor; sequential multiple ... See more keywords
Comparing adaptive interventions under a general sequential multiple assignment randomized trial design via multiple comparisons with the best
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Statistical Planning and Inference"
DOI: 10.1016/j.jspi.2020.06.008
Abstract: Abstract This paper considers screening of adaptive interventions or adaptive treatment strategies embedded in a sequential multiple assignment randomized trial (SMART). As a SMART typically consists of numerous adaptive interventions, inferential procedures based on pairwise… read more here.
Keywords: trial; multiple assignment; adaptive interventions; randomized trial ... See more keywords
Sequential Multiple Borylation Toward an Ultrapure Green Thermally Activated Delayed Fluorescence Material.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10946
Abstract: Multiple-resonance thermally activated delayed fluorescence (MR-TADF) emitters have emerged as an important component of organic light-emitting diodes (OLEDs) because of their narrowband emission and high exciton utilization efficiency. However, the chemical space of MR-TADF emitters… read more here.
Keywords: sequential multiple; thermally activated; delayed fluorescence; activated delayed ... See more keywords
Interim monitoring in sequential multiple assignment randomized trials.
Sign Up to like & getrecommendations! Published in 2021 at "Biometrics"
DOI: 10.1111/biom.13562
Abstract: A sequential multiple assignment randomized trial (SMART) facilitates the comparison of multiple adaptive treatment strategies (ATSs) simultaneously. Previous studies have established a framework to test the homogeneity of multiple ATSs by a global Wald test… read more here.
Keywords: multiple assignment; monitoring sequential; interim monitoring; sequential multiple ... See more keywords
Efficient and robust approaches for analysis of sequential multiple assignment randomized trials: Illustration using the ADAPT-R trial.
Sign Up to like & getrecommendations! Published in 2022 at "Biometrics"
DOI: 10.1111/biom.13808
Abstract: Personalized intervention strategies, in particular those that modify treatment based on a participant's own response, are a core component of precision medicine approaches. Sequential multiple assignment randomized trials (SMARTs) are growing in popularity and are… read more here.
Keywords: sequential multiple; adapt trial; assignment randomized; multiple assignment ... See more keywords
Interim monitoring of sequential multiple assignment randomized trials using partial information.
Sign Up to like & getrecommendations! Published in 2022 at "Biometrics"
DOI: 10.1111/biom.13854
Abstract: The sequential multiple assignment randomized trial (SMART) is the gold standard trial design to generate data for the evaluation of multi-stage treatment regimes. As with conventional (single-stage) randomized clinical trials, interim monitoring allows early stopping;… read more here.
Keywords: sequential multiple; interim monitoring; assignment randomized; using partial ... See more keywords
Baseline data of a sequential multiple assignment randomized trial (STEP study)
Sign Up to like & getrecommendations! Published in 2022 at "Early Intervention in Psychiatry"
DOI: 10.1111/eip.13263
Abstract: Research has shown that preventative intervention in individuals at ultra‐high risk of psychosis (UHR) improves symptomatic and functional outcomes. The staged treatment in early psychosis (STEP) trial aims to determine the most effective type, timing… read more here.
Keywords: sequential multiple; baseline data; step; trial ... See more keywords
Sample size considerations for comparing dynamic treatment regimens in a sequential multiple-assignment randomized trial with a continuous longitudinal outcome
Sign Up to like & getrecommendations! Published in 2019 at "Statistical Methods in Medical Research"
DOI: 10.1177/0962280219877520
Abstract: Clinicians and researchers alike are increasingly interested in how best to personalize interventions. A dynamic treatment regimen is a sequence of prespecified decision rules which can be used to guide the delivery of a sequence… read more here.
Keywords: multiple assignment; trial; randomized trial; sequential multiple ... See more keywords