Assessing treatment benefit in the presence of placebo response using the sequential parallel comparison design.
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DOI: 10.1002/sim.9349
Abstract: In clinical trials, placebo response is considered a beneficial effect arising from multiple factors, including the patient's expectations for the treatment. Its presence makes the classical parallel study design suboptimal and can bias the inference.… read more here.
Keywords: design; placebo response; treatment; sequential parallel ... See more keywords
Placebo Response as a Latent Characteristic: Application to Analysis of Sequential Parallel Comparison Design Studies
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DOI: 10.1080/01621459.2017.1375930
Abstract: ABSTRACT In clinical trials, placebo response can affect the inference about efficacy of the studied treatment. It is important to have a robust way to classify trial subjects with respect to their response to placebo.… read more here.
Keywords: response; latent characteristic; placebo response; response latent ... See more keywords