Asymmetric inner wedge group sequential tests with applications to verifying whether effective drug concentrations are similar in adults and children.
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DOI: 10.1002/sim.7154
Abstract: Extrapolating from information available on one patient group to support conclusions about another is common in clinical research. For example, the findings of clinical trials, often conducted in highly selective patient cohorts, are routinely extrapolated… read more here.
Keywords: sequential tests; group; group sequential; drug ... See more keywords