In Situ Injectable Sequentially Responsive Hydrogel Based on Triblock Copolymers for Breast Cancer Theranostic Amplification.
Sign Up to like & getrecommendations! Published in 2025 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.5c00320
Abstract: Celastrol (Cel), a natural small molecule, effectively inhibits breast cancer but has poor solubility and systemic toxicity. Herein, an in situ injectable sequentially responsive celastrol hydrogel (FCPC) based on the temperature-sensitive poloxamer F127 and tumor-acidity-cleavable… read more here.
Keywords: situ injectable; sequentially responsive; breast cancer; responsive hydrogel ... See more keywords
Construction of a sequentially responsive nanocarrier for chemotherapy and cascade amplified NIR photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc05122a
Abstract: A sequentially responsive nanocarrier was fabricated with three-in-one functional integration: bio-imaging, tumor microenvironment responsive chemotherapy and cascade activation of upconversion photodynamic therapy. The designed DNA outer nanoshell displayed site-specific degradation and controlled degradation speed. Significantly,… read more here.
Keywords: responsive nanocarrier; photodynamic therapy; chemotherapy cascade; sequentially responsive ... See more keywords