A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06751-8
Abstract: Homeostatic regulation of G-quadruplexes (G4s), four-stranded structures that can form in guanine-rich nucleic acids, requires G4 unwinding helicases. The mechanisms that mediate G4 unwinding remain unknown. We report the structure of a bacterial RecQ DNA… read more here.
Keywords: flipping sequestration; sequestration mechanism; recq; guanine flipping ... See more keywords
The sequestration mechanism as a generalizable approach to improve the sensitivity of biosensors and bioassays
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc03901j
Abstract: Biosensors and bioassays, both of which employ proteins and nucleic acids to detect specific molecular targets, have seen significant applications in both biomedical research and clinical practice. This success is largely due to the extraordinary… read more here.
Keywords: biosensors bioassays; sequestration mechanism; sensitivity; concentration ... See more keywords