Mutation familiale de l’ARN de transfert de la sélénocystéine (tRNA[Ser]Sec) : évaluation clinique et hormonale chez 2 patients
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.06.137
Abstract: Introduction La synthese des selenoproteines necessite l’insertion d’une seleneocysteine par un complexe multi-proteique comprenant le tRNA[Ser]Sec. Une mutation du gene TRU-TCA1-1, codant pour le tRNA[Ser]Sec a ete recemment decrite, responsable d’une diminution de l’expression des… read more here.
Keywords: trna ser; chez; ser sec; mutation ... See more keywords
A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad482
Abstract: The selenocysteine (Sec) tRNA (tRNA[Ser]Sec) governs Sec insertion into selenoproteins by the recoding of a UGA codon, typically used as a stop codon. A homozygous point mutation (C65G) in the human tRNA[Ser]Sec acceptor arm has… read more here.
Keywords: trna ser; uga recoding; ser sec; mutation ... See more keywords