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   Articles with "serca" as a keyword



Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202507210

Abstract: SYNTAXIN 12/13 (STX12), a member of the syntaxin protein family enriched in the brain and heart, plays important roles in vesicle recycling. Currently, the role of STX12 in cardiovascular physiology remains unclear. Using zebrafish and… read more here.

Keywords: syntaxin; serca; heart; stx12 ... See more keywords
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A Role for SERCA Pumps in the Neurobiology of Neuropsychiatric and Neurodegenerative Disorders.

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recommendations! Published in 2020 at "Advances in experimental medicine and biology"

DOI: 10.1007/978-3-030-12457-1_6

Abstract: Calcium (Ca2+) is a fundamental regulator of cell fate and intracellular Ca2+ homeostasis is crucial for proper function of the nerve cells. Given the complexity of neurons, a constellation of mechanisms finely tunes the intracellular… read more here.

Keywords: serca pumps; serca; role serca; ca2 ... See more keywords

Elucidating the Uncoupling of ATP Hydrolysis and Ca2+ Transport in SERCA by Sarcolipin

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.2708

Abstract: The activity of the sarco(endo)plasmic reticulum Ca2+ -ATPase (SERCA), which plays a key role in muscle contraction and relaxation, is regulated by sarcolipin (SLN), a 31-residue transmembrane peptide. Sarcolipin has been shown to uncouple ATP… read more here.

Keywords: atp hydrolysis; serca; hydrolysis ca2; ca2 transport ... See more keywords

Primitive Phospholamban- and Sarcolipin-like Peptides Inhibit the Sarcoplasmic Reticulum Calcium Pump SERCA.

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recommendations! Published in 2022 at "Biochemistry"

DOI: 10.1021/acs.biochem.2c00246

Abstract: Intracellular calcium signaling is essential for all kingdoms of life. An important part of this process is the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA), which maintains the low cytosolic calcium levels required for intracellular calcium homeostasis. In… read more here.

Keywords: phospholamban sarcolipin; serca; calcium pump; calcium ... See more keywords

CBP/CREB Regulates the Proliferation and Apoptosis of Cardiomyocytes by Interacting With SERCA

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recommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.70426

Abstract: Tetralogy of Fallot (TOF) is a common congenital heart disease. In this study, we proposed that cAMP response element‐binding protein (CREB)‐binding protein (CBP) regulates the proliferation and apoptosis in TOF by interacting with the sarco/endoplasmic… read more here.

Keywords: serca; regulates proliferation; tof patients; creb ... See more keywords

Matrix Metalloproteinase-2 Proteolyzes the Sarcoplasmic Reticulum Calcium ATPase (SERCA), thus Resulting in Morphofunctional Vascular Alterations in Arterial Hypertension

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5731655

Abstract: Introduction: Arterial hypertension is characterized by matrix metalloproteinase (MMP)-2 increased activity, which proteolyzes extra- and intracellular proteins, thus contributing to cellular migration and proliferation and resulting in vascular remodeling and dysfunction. MMP-2 also proteolyzes the… read more here.

Keywords: calcium; hypertension; serca; physiology ... See more keywords

Low-dose lithium chloride supplementation protects cardiac SERCA function during heat stress

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5732997

Abstract: Background: The sarco(endo)plasmic reticulum calcium (Ca2+)-ATPase (SERCA) is responsible for ~70% of intracellular Ca2+ removal in cardiac muscle contributing to the regulation of cardiac relaxation and contractility. SERCA is susceptible to heightened oxidative stress that… read more here.

Keywords: serca; physiology; function; heat stress ... See more keywords

High Glucose Alters Endoplasmic Reticulum Ca2+ Stores in T Lymphocytes Revealing Potential Novel Therapeutic Targets for Diabetic-Induced Immune Dysfunction

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recommendations! Published in 2024 at "Physiology"

DOI: 10.1152/physiol.2024.39.s1.1620

Abstract: The objective of this study was to examine the effects of high glucose stress on endoplasmic reticulum (ER) Ca2+ stores in T lymphocytes. Our hypothesis is that T lymphocytes exposed to chronic high glucose undergo… read more here.

Keywords: serca; high glucose; ca2 stores; physiology ... See more keywords

Abstract B113: Selective blockade of oncogenic NOTCH1 with the new SERCA inhibitor CAD204520 in T-cell acute lymphoblastic leukemia

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recommendations! Published in 2019 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.targ-19-b113

Abstract: Given its oncogenic role in human cancers, Notch1 signaling has garnered increased attention as a therapeutic target. Several Notch modulators, including γ-secretase inhibitors, have shown therapeutic efficacy in preclinical tumor models. However, despite this promise,… read more here.

Keywords: leukemia; cad204520; atpase; cell ... See more keywords
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Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice

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recommendations! Published in 2020 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22010037

Abstract: Sarcopenia has a significant negative impact on healthspan in the elderly and effective pharmacologic interventions remain elusive. We have previously demonstrated that sarcopenia is associated with reduced activity of the sarcoplasmic reticulum Ca2+ ATPase (SERCA)… read more here.

Keywords: serca; muscle; serca activity; sarcoplasmic reticulum ... See more keywords

Anti-Cancer SERCA Inhibitors Targeting Sorafenib-Resistant Human Papillary Thyroid Carcinoma

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24087069

Abstract: Thyroid cancer is generally curable and, in many cases, can be completely treated, although it can sometimes recur after cancer therapy. Papillary thyroid cancer (PTC) is known as one of the most general subtypes of… read more here.

Keywords: thyroid; anti cancer; sorafenib resistant; serca ... See more keywords