Targeting the Ubiquitin-Proteasome System in Limb-Girdle Muscular Dystrophy With CAPN3 Mutations
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DOI: 10.3389/fcell.2022.822563
Abstract: LGMDR1 is caused by mutations in the CAPN3 gene that encodes calpain 3 (CAPN3), a non-lysosomal cysteine protease necessary for proper muscle function. Our previous findings show that CAPN3 deficiency leads to reduced SERCA levels… read more here.
Keywords: muscle; serca levels; ubiquitin proteasome; protein ... See more keywords