Novel Approach to Study SERCA Function In Situ
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2165
Abstract: Previously used techniques to measure the sarcoplasmic/endoplasmic reticulum Ca-ATPase (SERCA) function either are cell destructive or lack sensitivity. We designed a new approach that allows studying SERCA function in the cellular environment under well-controlled conditions.… read more here.
Keywords: serca function; cells expressing; study; serca2a ... See more keywords
Dimerization of SERCA2a Enhances Transport Rate and Improves Energetic Efficiency in Living Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.08.025
Abstract: The type 2a sarco/endoplasmic reticulum (ER) Ca2+-ATPase (SERCA2a) plays a key role in intracellular Ca2+ regulation in the heart. We have previously shown evidence of stable homodimers of SERCA2a in heterologous cells and cardiomyocytes. However,… read more here.
Keywords: dimerization; transport; serca2a; rate ... See more keywords
Small molecule activator of Serca2a improves myocardial bioenergetics and lipid metabolism in diabetic mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734702
Abstract: Background: Altered calcium homeostasis, insulin resistance, and dysregulated energy metabolism are major causes of diabetic cardiomyopathy. The expression and activity of Sarco/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) are decreased in the diabetic heart failure. Increasing SERCA2a… read more here.
Keywords: serca2a; diabetic mice; physiology; heart ... See more keywords
Abstract 144: Ultrasound Mediated Transfection of SERCA2a and Cx43 Genes Assisted Bone Marrow Stem Cells Transplantation to Improve Heart Failure and Ventricular Arrhythmia After Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.144
Abstract: Objective: We aimed to investigate the possibility of combining BMSCs transplantation (BMSCs T) with sarcoplasmic reticulum Ca2+ATase (SERCA2a) and connexins 43 (Cx43) genes transfection mediated by ultrasound-targeted microbubble destruction (UTMD) to treat heart failure (HF)… read more here.
Keywords: bmscs utmd; serca2a; utmd serca2a; serca2a cx43 ... See more keywords
Epigallocatechin-3 gallate prevents pressure overload-induced heart failure by up-regulating SERCA2a via histone acetylation modification in mice
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0205123
Abstract: Heart failure is a common, costly, and potentially fatal condition. The cardiac sarcoplasmic reticulum Ca-ATPase (SERCA2a) plays a critical role in the regulation of cardiac function. Previously, low SERCA2a expression was revealed in mice with… read more here.
Keywords: heart; group; heart failure; serca2a ... See more keywords
Characterization of the PLN p.Arg14del Mutation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of molecular sciences"
DOI: 10.3390/ijms222413500
Abstract: Phospholamban (PLN) is the natural inhibitor of the sarco/endoplasmic reticulum Ca2+ ATP-ase (SERCA2a). Heterozygous PLN p.Arg14del mutation is associated with an arrhythmogenic dilated cardiomyopathy (DCM), whose pathogenesis has been attributed to SERCA2a "superinhibition". AIM To… read more here.
Keywords: arg14del mutation; serca2a; pln arg14del;
Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca2+ Handling and Arrhythmogenesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23136947
Abstract: Phospholamban (PLN), a key modulator of Ca2+-homeostasis, inhibits sarcoplasmic reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility. The human PLN mutation R14del has been identified in arrhythmogenic cardiomyopathy patients worldwide and is currently extensively investigated.… read more here.
Keywords: inhibition; serca2a; r14del; pln r14del ... See more keywords
Attenuation of the upregulation of NF-κB and AP-1 DNA-binding activities induced by tunicamycin or hypoxia/reoxygenation in neonatal rat cardiomyocytes by SERCA2a overexpression
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2021.4946
Abstract: The present study aimed to investigate the effects of the overexpression of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2a) on endoplasmic reticulum (ER) stress (ERS)-associated inflammation in neonatal rat cardiomyocytes (NRCMs) induced by tunicamycin (TM) or hypoxia/reoxygenation (H/R).… read more here.
Keywords: overexpression; serca2a; dna binding; overexpression serca2a ... See more keywords