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Published in 2017 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-017-1394-z
Abstract: Renal fibrosis is an important factor for end-stage renal failure. However, only few therapeutic options for its treatment are established. Zaprinast, a phosphodiesterase 5 inhibitor, and serelaxin, the recombinant form of the naturally occurring hormone…
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Keywords:
combination;
fibrosis;
serelaxin;
zaprinast ... See more keywords
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Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.04.009
Abstract: BACKGROUND AND PURPOSE Recombinant human relaxin-2, serelaxin, is being proved as a novel drug with therapeutic efficacy in some cardiovascular diseases, especially heart failure, a disease whose physiopathology and course are firmly correlated with important…
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Keywords:
human relaxin;
serelaxin;
treatment;
fatty acids ... See more keywords
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Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.10.004
Abstract: Abstract Serelaxin, a recombinant form of human relaxin‐2, is currently regarded as a novel drug for treatment of acute heart failure. However, whether therapeutic effects of serelaxin are achieved by inhibiting cardiac fibrosis remains unclear.…
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Keywords:
cardiac fibroblasts;
alk smad2;
differentiation;
serelaxin ... See more keywords
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Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65144-4
Abstract: Germinal matrix hemorrhage (GMH) is a detrimental form of neonatal CNS injury. Following GMH-mediated eNOS inhibition, inflammation arises, contributing to GMH-induced brain injury. We investigated the beneficial effects of Serelaxin, a clinical tested recombinant Relaxin-2…
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Keywords:
serelaxin;
inflammation;
gmh induced;
matrix hemorrhage ... See more keywords
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Published in 2017 at "PLoS Medicine"
DOI: 10.1371/journal.pmed.1002248
Abstract: Background Chronic liver scarring from any cause leads to cirrhosis, portal hypertension, and a progressive decline in renal blood flow and renal function. Extreme renal vasoconstriction characterizes hepatorenal syndrome, a functional and potentially reversible form…
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Keywords:
renal dysfunction;
serelaxin;
dysfunction;
cirrhosis ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098356
Abstract: Fibrosis is the late stage of thyroid-associated ophthalmopathy (TAO), resulting in serious complications. Effective therapeutic drugs are still lacking. We aimed to explore the mechanism of TAO fibrosis and to find a targeted drug. High-throughput…
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Keywords:
serelaxin alleviates;
associated ophthalmopathy;
notch pathway;
serelaxin ... See more keywords
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Published in 2020 at "Theranostics"
DOI: 10.7150/thno.38640
Abstract: Rationale: Cardiac fibrosis is an integral constituent of every form of chronic heart disease, and persistence of fibrosis reduces tissue compliance and accelerates the progression to heart failure. Relaxin-2 is a human hormone, which has…
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Keywords:
rxfp1;
heart;
fibrosis;
serelaxin ... See more keywords