Abstract 3714: Microscopic mayhem: Serial killing and other immune cell dynamics captured in situ
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3714
Abstract: Critical to advancing immunotherapy and cell therapy in cancer is developing a deeper understanding pf the dynamics of immune cell-mediated cytotoxicity. The results from the multidisciplinary effort reported here include numerous movies of immune cell-mediated… read more here.
Keywords: cancer; serial killing; culture; cell ... See more keywords
The FcγRIIIA (CD16) L48-H/R polymorphism enhances NK cell-mediated antibody-dependent cellular cytotoxicity by promoting serial killing.
Sign Up to like & getrecommendations! Published in 2024 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-24-0384
Abstract: Many tumor-specific monoclonal antibody therapies stimulate antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells through FcγRIIIa (CD16). The efficacy of these ADCC-based immunotherapies is potentiated in patients with the common CD16 polymorphic variant F158-V… read more here.
Keywords: antibody dependent; antibody; serial killing; cellular cytotoxicity ... See more keywords
Preclinical Development of Edit-201, a Multigene Edited Healthy Donor NK Cell with Enhanced Anti-Tumor Function and Superior Serial Killing Activity in an Immunosuppressive Environment
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DOI: 10.1182/blood-2020-139988
Abstract: Natural killer (NK) cells distinguish tumor from healthy tissue via multiple mechanisms, including recognition of stress ligands and loss of MHC class I expression. For example, KIR mismatching enables allogenic NK cells to respond to… read more here.
Keywords: medicine; serial killing; dko cells; editas medicine ... See more keywords