Articles with "series compartment" as a keyword



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Exploring the Pharmacokinetic Mysteries of the Liver: Application of Series Compartment Models of Hepatic Elimination

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Published in 2023 at "Drug Metabolism and Disposition"

DOI: 10.1124/dmd.122.001190

Abstract: Among the basic hepatic clearance models, the dispersion model (DM) is the most physiologically sound compared with the well-stirred model and the parallel tube model. However, its application in physiologically-based pharmacokinetic (PBPK) modeling has been… read more here.

Keywords: hepatic elimination; clint; scm; compartment models ... See more keywords