A High-Throughput Screening Triage Workflow to Authenticate a Novel Series of PFKFB3 Inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "SLAS Discovery"
DOI: 10.1177/2472555217732289
Abstract: A high-throughput screen (HTS) of human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) resulted in several series of compounds with the potential for further optimization. Informatics was used to identify active chemotypes with lead-like profiles and remove compounds that… read more here.
Keywords: pfkfb3; series compounds; high throughput; series ... See more keywords