Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases.
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DOI: 10.1016/j.ejmech.2017.11.061
Abstract: Coumarin derivatives are a peculiar class of inhibitors of the family of metalloenzymes carbonic anhydrases (CA, EC 4.2.1.1). Several coumarins display higher affinity and selectivity toward most relevant and druggable CA isoforms. By decorating the… read more here.
Keywords: coumarin based; coumarin; series coumarin; carbonic anhydrases ... See more keywords