Discovery of a novel series of hDHODH inhibitors with anti-pulmonary fibrotic activities.
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DOI: 10.1016/j.bioorg.2019.01.011
Abstract: Human dihydroorotate dehydrogenase (hDHODH) is a flavin-dependent enzyme essential to pyrimidine de novo biosynthesis, which serves as an attractive therapeutic target for the treatment of autoimmune disorders. A novel series of hDHODH inhibitors was developed… read more here.
Keywords: novel series; series hdhodh; hdhodh inhibitors; chemistry ... See more keywords