Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.
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DOI: 10.1021/acs.jmedchem.6b01620
Abstract: Herein we describe the design, synthesis, and evaluation of a novel series of oxadiazine-based gamma secretase modulators obtained via isosteric amide replacement and critical consideration of conformational restriction. Oxadiazine lead 47 possesses good in vitro… read more here.
Keywords: design synthesis; evaluation novel; novel series; series oxadiazine ... See more keywords