Elucidation of fluorine's impact on pKa and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors.
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DOI: 10.1039/c8md00114f
Abstract: P-Glycoprotein (Pgp)-mediated cellular efflux is recognized as a common challenge in CNS drug discovery. In this study, the influence of replacing a hydrogen atom with fluorine on the pKa and Pgp-mediated efflux is elucidated for… read more here.
Keywords: series pde9; pgp mediated; pka; mediated efflux ... See more keywords