Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
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DOI: 10.1021/acs.jmedchem.2c01964
Abstract: Herein, we report the optimization of a meta-substituted series of selective estrogen receptor degrader (SERD) antagonists for the treatment of ER+ breast cancer. Structure-based design together with the use of modeling and NMR to favor… read more here.
Keywords: estrogen receptor; series; series selective; receptor degrader ... See more keywords