Inhibition of glial D‐serine release rescues synaptic damage after brain injury
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24161
Abstract: Synaptic damage is one of the most prevalent pathophysiological responses to traumatic CNS injury and underlies much of the associated cognitive dysfunction; however, it is poorly understood. The D‐amino acid, D‐serine, serves as the primary… read more here.
Keywords: injury; synaptic damage; serine; brain ... See more keywords
Cerebrospinal fluid amino acids glycine, serine, and threonine in nonketotic hyperglycinemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12500
Abstract: Nonketotic hyperglycinemia (NKH) is caused by deficient glycine cleavage enzyme activity and characterized by elevated brain glycine. Metabolism of glycine is connected enzymatically to serine through serine hydroxymethyltransferase and shares transporters with serine and threonine.… read more here.
Keywords: serine threonine; glycine serine; nkh patients; serine ... See more keywords
Alterations in amino acid levels in mouse brain regions after adjunctive treatment of brexpiprazole with fluoxetine: comparison with (R)-ketamine
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4700-z
Abstract: RationaleBrexpiprazole, a serotonin–dopamine activity modulator, is approved in the USA as an adjunctive therapy to antidepressants for treating major depressive disorders. Similar to the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine, the combination of brexpiprazole and fluoxetine… read more here.
Keywords: brexpiprazole fluoxetine; combination; ketamine; serine ... See more keywords
Oral administration of d-serine prevents the onset and progression of colitis in mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-021-01792-1
Abstract: l-amino acids are the predominant forms of organic molecules on the planet, but recent studies have revealed that various foods contain d-amino acids, the enantiomers of l-amino acids. Though diet plays important roles in both… read more here.
Keywords: amino acids; serine; colitis; mice ... See more keywords
Vitamin B6 is essential for serine de novo biosynthesis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Inherited Metabolic Disease"
DOI: 10.1007/s10545-017-0061-3
Abstract: Pyridoxal 5′-phosphate (PLP), the metabolically active form of vitamin B6, plays an essential role in brain metabolism as a cofactor in numerous enzyme reactions. PLP deficiency in brain, either genetic or acquired, results in severe… read more here.
Keywords: serine novo; biosynthesis; vitamin essential; serine glycine ... See more keywords
Serine Racemase Expression by Striatal Neurons
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DOI: 10.1007/s10571-020-00880-9
Abstract: d -serine is synthesized by serine racemase (SR) and is a co-agonist at forebrain N -methyl- d -aspartate receptors (NMDARs). d -serine and SR are expressed primarily in neurons, but not in quiescent astrocytes. In… read more here.
Keywords: serine racemase; serine; expression; mice ... See more keywords
First-principles study of interaction of serine with nucleobases of DNA and RNA
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biological Physics"
DOI: 10.1007/s10867-016-9436-1
Abstract: The nature of interaction between serine—a vital molecule for cancer cell proliferation and nucleic acid bases—adenine (A), guanine (G), cytosine (C), thymine (T), and uracil (U) is investigated within the framework of Møller–Plesset perturbation theory… read more here.
Keywords: serine; interaction serine; serine guanine; interaction ... See more keywords
l-Serine-Mediated Neuroprotection Includes the Upregulation of the ER Stress Chaperone Protein Disulfide Isomerase (PDI)
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9817-7
Abstract: The unfolded protein response (UPR) is a highly evolutionarily conserved response to endoplasmic reticulum (ER) stress, which functions to return cells to homeostasis or send them into apoptosis, depending on the degree of cellular damage.… read more here.
Keywords: protein; disulfide isomerase; serine; protein disulfide ... See more keywords
Solid-state vibrational circular dichroism studies of L- and D-serine.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2019.05.016
Abstract: d-Serine is considered a key endogenous substance involved in several enzymatic reactions in the human body. In this study, solid-state vibrational circular dichroism (VCD) measurements of enantiomeric serine were performed for spectroscopic distinction between d-… read more here.
Keywords: solid state; state; state vibrational; circular dichroism ... See more keywords
The PHGDH enigma: do cancer cells only need serine or also a redox modulator?
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.01.036
Abstract: Upregulation of serine biosynthesis pathway activity is an increasingly apparent feature of many cancers. Most notably, the first rate-limiting enzyme of the pathway, phosphoglycerate dehydrogenase (PHGDH), is genomically amplified in some melanomas and breast cancers… read more here.
Keywords: phgdh enigma; enigma cancer; serine; cancer cells ... See more keywords
Protein kinase C phosphorylates the EphA2 receptor on serine 892 in the regulatory linker connecting the kinase and SAM domains.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109668
Abstract: The EphA2 receptor tyrosine kinase signals through two distinct mechanisms, one regulated by tyrosine phosphorylation and the other by serine/threonine phosphorylation. Serine 892 (S892) is one of the major serine/threonine phosphorylation sites in EphA2, but… read more here.
Keywords: kinase; serine; linker; kinase sam ... See more keywords