Serine 408 phosphorylation is a molecular switch that regulates structure and function of the occludin α-helical bundle
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DOI: 10.1073/pnas.2204618119
Abstract: Significance Tight junctions form selectively permeable seals that limit paracellular flux. Increased tight junction permeability has been associated with intestinal disease. Previous studies indicate that casein kinase 2 (CK2) phosphorylates S408 within an unstructured region… read more here.
Keywords: tight junction; phosphorylation; helical bundle; serine 408 ... See more keywords