HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
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DOI: 10.1038/s41467-021-21302-4
Abstract: Upon binding to DNA breaks, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other factors to initiate DNA repair. Serine is the major residue for ADP-ribosylation upon DNA damage, which strictly depends on HPF1. Here, we… read more here.
Keywords: serine adp; adp ribosylation; parp1; hpf1 ... See more keywords