Novel Serine-Arginine Protein Kinase Inhibitors for Treating Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00132
Abstract: Described herein are novel serine-arginine protein kinase (SRPK) inhibitors, their pharmaceutical compositions, the use of such compounds in treating cancer, and processes for preparing such compounds. read more here.
Keywords: protein kinase; serine arginine; treating cancer; arginine protein ... See more keywords
Increased expression of SRPK1 (serine/arginine-rich protein-specific kinase 1) is associated with progression and unfavorable prognosis in cervical squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2034705
Abstract: ABSTRACT Previous studies suggest that SRPK1 (serine/arginine-rich protein-specific kinase 1) is involved in tumorigenesis and closely related to unfavorable outcomes. However, its expression pattern in cervical squamous cell carcinoma (CESC) remains uncovered. In this study,… read more here.
Keywords: expression; serine arginine; srpk1; protein ... See more keywords
Targeting hepatic serine-arginine protein kinase 2 ameliorates alcohol-associated liver disease by alternative splicing control of lipogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000433
Abstract: BACKGROUND AIMS Lipid accumulation induced by alcohol consumption is not only an early pathophysiological response but also a prerequisite for the progression of alcohol-associated liver disease (ALD). Alternative splicing regulates gene expression and protein diversity;… read more here.
Keywords: srpk2; serine arginine; kinase; alternative splicing ... See more keywords
Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/3819719
Abstract: Serine/arginine-rich splicing factors (SRSFs) have one or two RNA recognition motifs in the N terminal and a serine/arginine-enriched domain in the C terminal. SRSFs are essential components of spliceosomes and are involved in alternative splicing,… read more here.
Keywords: arginine rich; physiological pathological; serine arginine; rich splicing ... See more keywords
Impaired expression of serine/arginine protein kinase 2 (SRPK2) affects melanoma progression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.979735
Abstract: Melanoma is one of the most aggressive tumors, and its lethality is associated with the ability of malignant cells to migrate and invade surrounding tissues to colonize distant organs and to generate widespread metastasis. The… read more here.
Keywords: melanoma; progression; serine arginine; melanoma progression ... See more keywords
Identification and Regulation of Tomato Serine/Arginine-Rich Proteins Under High Temperatures
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.645689
Abstract: Alternative splicing is an important mechanism for the regulation of gene expression in eukaryotes during development, cell differentiation or stress response. Alterations in the splicing profiles of genes under high temperatures that cause heat stress… read more here.
Keywords: arginine rich; high temperatures; response; serine arginine ... See more keywords
Genome-Wide Characterization of Serine/Arginine-Rich Gene Family and Its Genetic Effects on Agronomic Traits of Brassica napus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.829668
Abstract: Serine/arginine-rich (SR) proteins are indispensable factors for RNA splicing, and they play important roles in development and abiotic stress responses. However, little information on SR genes in Brassica napus is available. In this study, 59… read more here.
Keywords: serine arginine; arginine rich; brassica napus; agronomic traits ... See more keywords
Effects of Serine/Arginine Enriched Protein BmUP on the Development of Male Silkworm Reproductive Organs
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44020061
Abstract: Serine/arginine-rich proteins are a class of highly conserved splicing factor proteins involved in constitutive and alternative splicing. We screened a low molecular weight serine/arginine rich protein from silkworms and named it BmUP. Temporal and spatial… read more here.
Keywords: male; serine arginine; arginine; expression ... See more keywords
The Immunohistochemical Expression of the Serine and Arginine-Rich Splicing Factor 1 (SRSF1) Is a Predictive Factor of the Recurrence of Basal Cell Carcinoma: A Preliminary Study on a Series of 52 Cases
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58010139
Abstract: Background and Objectives: Basal cell carcinomas (BCCs) are the most frequent skin tumors; although they usually exhibit a good prognosis, it has been reported that there is a 2–8% rate of local recurrence of surgically-excised… read more here.
Keywords: serine arginine; arginine rich; local recurrence; factor ... See more keywords
Genome-Wide Analysis of Serine/Arginine-Rich Protein Family in Wheat and Brachypodium distachyon
Sign Up to like & getrecommendations! Published in 2019 at "Plants"
DOI: 10.3390/plants8070188
Abstract: By regulating the pre-mRNA splicing of other genes and themselves, plant serine/arginine-rich (SR) proteins play important roles in development and in response to abiotic stresses. Presently, the functions of most plant SR protein genes remain… read more here.
Keywords: protein; arginine rich; protein genes; serine arginine ... See more keywords
Knockdown of Serine–Arginine Protein Kinase 1 Inhibits the Growth and Migration in Renal Cell Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Research"
DOI: 10.3727/096504016x14743324568129
Abstract: The pre-mRNA splicing regulator serine–arginine protein kinase 1 (SRPK1), a member of the SR kinase family, plays an essential role in cancer development and various pathophysiological processes. However, its expression pattern and functions in renal… read more here.
Keywords: renal cell; serine arginine; rcc; protein kinase ... See more keywords