Deletion of gene gnd encoding 6-phosphogluconate dehydrogenase promotes l-serine biosynthesis in a genetically engineered strain of Methylobacterium sp. MB200
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology Letters"
DOI: 10.1007/s10529-018-2615-3
Abstract: ObjectiveTo identify potential target genes involved in l-serine biosynthesis in Methylobacterium sp. MB200 and to evaluate the gnd genetically-engineered strains for l-serine production.ResultsFive genes that are not associated with the central metabolic pathway but with… read more here.
Keywords: methylobacterium mb200; serine biosynthesis; gnd; methylobacterium ... See more keywords
The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.086
Abstract: NAD+ is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD+ salvage pathway. Here, we find that inhibiting the NAD+ salvage pathway depletes serine biosynthesis from glucose by impeding the NAD+-dependent protein,… read more here.
Keywords: serine biosynthesis; salvage pathway; nad salvage; salvage ... See more keywords
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.11.027
Abstract: In tumors, nutrient availability and metabolism are known to be important modulators of growth signaling. However, it remains elusive whether cancer cells that are growing out in the metastatic niche rely on the same nutrients… read more here.
Keywords: serine biosynthesis; breast; breast tumors; cancer ... See more keywords
Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28272-1
Abstract: Sustained mitochondrial fitness relies on coordinated biogenesis and clearance. Both processes are regulated by constant targeting of proteins into the organelle. Thus, mitochondrial protein import sets the pace for mitochondrial abundance and function. However, our… read more here.
Keywords: mitochondrial protein; novo serine; serine biosynthesis; protein import ... See more keywords
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac305
Abstract: AIMS Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of DCM, the molecular mechanisms underlying the pathogenesis of familial DCM remain unknown, translating to… read more here.
Keywords: serine biosynthesis; ipsc cms; dcm ipsc; dcm ... See more keywords
The phosphorylated pathway of serine biosynthesis links plant growth with nitrogen metabolism.
Sign Up to like & getrecommendations! Published in 2021 at "Plant physiology"
DOI: 10.1093/plphys/kiab167
Abstract: Because it is the precursor for various essential cellular components, the amino acid serine is indispensable for every living organism. In plants, serine is synthesized by two major pathways: photorespiration and the phosphorylated pathway of… read more here.
Keywords: metabolism; serine biosynthesis; plant growth; plant ... See more keywords
Serine biosynthesis is a metabolic vulnerability in FLT3-ITD-driven acute myeloid leukaemia.
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DOI: 10.1158/2159-8290.cd-20-0738
Abstract: Internal tandem duplication of the FMS-like tyrosine kinase 3 gene (FLT3-ITD) occurs in 30% of poor prognosis acute myeloid leukaemias (AMLs). Limited clinical efficacy of FLT3 inhibitors highlights the need for alternative therapeutic modalities in… read more here.
Keywords: serine biosynthesis; flt3 itd; itd; acute myeloid ... See more keywords
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201910491
Abstract: During obesity, macrophages infiltrate the breast tissue leading to low‐grade chronic inflammation, a factor considered responsible for the higher risk of breast cancer associated with obesity. Here, we formally demonstrate that breast epithelial cells acquire… read more here.
Keywords: serine biosynthesis; biosynthesis pathway; breast; breast cancer ... See more keywords