Identification of covalent inhibitors that disrupt M. tuberculosis growth by targeting multiple serine hydrolases involved in lipid metabolism.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.08.013
Abstract: The increasing incidence of antibiotic-resistant Mycobacterium tuberculosis infections is a global health threat necessitating the development of new antibiotics. Serine hydrolases (SHs) are a promising class of targets because of their importance for the synthesis… read more here.
Keywords: covalent inhibitors; identification covalent; serine hydrolases; tuberculosis growth ... See more keywords
Characterization of serine hydrolases across clinical isolates of commensal skin bacteria Staphylococcus epidermidis using activity-based protein profiling.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00095
Abstract: The bacterial genus Staphylococcus comprises diverse species that colonize the skin as commensals but can also cause infection. Previous work identified a family of serine hydrolases termed fluorophoshonate binding hydrolases (Fphs) in the pathogenic bacteria… read more here.
Keywords: based protein; serine hydrolases; activity based; bacteria staphylococcus ... See more keywords
Functional annotation of serine hydrolases in the asexual erythrocytic stage of Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-54009-0
Abstract: Enzymes of the serine hydrolase superfamily are ubiquitous, highly versatile catalysts that mediate a wide variety of metabolic reactions in eukaryotic cells, while also being amenable to selective inhibition. We have employed a fluorophosphonate-based affinity… read more here.
Keywords: erythrocytic stage; serine hydrolases; serine; asexual erythrocytic ... See more keywords
Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function?
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126851
Abstract: The metabolic state of pregnant women and their unborn children changes throughout pregnancy and adapts to the specific needs of each gestational week. These adaptions are accomplished by the actions of enzymes, which regulate the… read more here.
Keywords: lipid homeostasis; placental function; targets placental; pregnancy ... See more keywords
First Identification of a Large Set of Serine Hydrolases by Activity-Based Protein Profiling in Dibutyl Phthalate-Exposed Zebrafish Larvae
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416060
Abstract: Despite the involvement of several serine hydrolases (SHs) in the metabolism of xenobiotics such as dibutyl phthalate (DBP), no study has focused on mapping this enzyme class in zebrafish, a model organism frequently used in… read more here.
Keywords: dibutyl phthalate; dbp; zebrafish larvae; activity based ... See more keywords