Effects of serine palmitoyltransferase inhibition by myriocin in ad libitum-fed and nutrient-restricted ewes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of animal science"
DOI: 10.1093/jas/skab221
Abstract: The fungal isolate myriocin inhibits serine palmitoyltransferase and de novo ceramide synthesis in rodents; however, the effects of myriocin on ceramide concentrations and metabolism have not been previously investigated in ruminants. In our study, twelve… read more here.
Keywords: ceramide; nutrient restriction; serine palmitoyltransferase; myriocin ... See more keywords
Phosphorylation of the LCB1 subunit of Arabidopsis serine palmitoyltransferase stimulates its activity and modulates sphingolipid biosynthesis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13461
Abstract: Sphingolipids are the structural components of membrane lipid bilayers and act as signaling molecules in many cellular processes. Serine palmitoyltransferase (SPT) is the first committed and rate-limiting enzyme in the de novo sphingolipids biosynthetic pathway.… read more here.
Keywords: spt activity; serine palmitoyltransferase; lcb1; activity ... See more keywords
Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01331-22
Abstract: Targeting the cellular sphingolipid metabolism is often discussed as a potential approach to treat associated human diseases such as cancer and Alzheimer's disease. Alternatively, it is also a possible target for the development of antifungal… read more here.
Keywords: polyketide tail; inhibition; serine palmitoyltransferase; palmitoyltransferase ... See more keywords
Erratum: Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Lipid Research"
DOI: 10.1194/jlr.err119000228
Abstract: Isotope labels are frequently used tools to track metabolites through complex biochemical pathways and to discern the mechanisms of enzyme-catalysed reactions. Isotopically-labelled Lserine is often used to monitor the activity of the first enzyme in… read more here.
Keywords: isotopically labeled; use isotopically; serine palmitoyltransferase; serine ... See more keywords
Serine Palmitoyltransferase (SPT)-related Neurodegenerative and Neurodevelopmental Disorders
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuromuscular Diseases"
DOI: 10.3233/jnd-240014
Abstract: Motor neuron diseases and peripheral neuropathies are heterogeneous groups of neurodegenerative disorders that manifest with distinct symptoms due to progressive dysfunction or loss of specific neuronal subpopulations during different stages of development. A few monogenic,… read more here.
Keywords: spt related; palmitoyltransferase; serine palmitoyltransferase; related neurodegenerative ... See more keywords