Effects of serine palmitoyltransferase inhibition by myriocin in ad libitum-fed and nutrient-restricted ewes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of animal science"
DOI: 10.1093/jas/skab221
Abstract: The fungal isolate myriocin inhibits serine palmitoyltransferase and de novo ceramide synthesis in rodents; however, the effects of myriocin on ceramide concentrations and metabolism have not been previously investigated in ruminants. In our study, twelve… read more here.
Keywords: ceramide; nutrient restriction; serine palmitoyltransferase; myriocin ... See more keywords
Phosphorylation of the LCB1 subunit of Arabidopsis serine palmitoyltransferase stimulates its activity and modulates sphingolipid biosynthesis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13461
Abstract: Sphingolipids are the structural components of membrane lipid bilayers and act as signaling molecules in many cellular processes. Serine palmitoyltransferase (SPT) is the first committed and rate-limiting enzyme in the de novo sphingolipids biosynthetic pathway.… read more here.
Keywords: spt activity; serine palmitoyltransferase; lcb1; activity ... See more keywords
Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01331-22
Abstract: Targeting the cellular sphingolipid metabolism is often discussed as a potential approach to treat associated human diseases such as cancer and Alzheimer's disease. Alternatively, it is also a possible target for the development of antifungal… read more here.
Keywords: polyketide tail; inhibition; serine palmitoyltransferase; palmitoyltransferase ... See more keywords
Erratum: Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Lipid Research"
DOI: 10.1194/jlr.err119000228
Abstract: Isotope labels are frequently used tools to track metabolites through complex biochemical pathways and to discern the mechanisms of enzyme-catalysed reactions. Isotopically-labelled Lserine is often used to monitor the activity of the first enzyme in… read more here.
Keywords: isotopically labeled; use isotopically; serine palmitoyltransferase; serine ... See more keywords