Structural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl-fluoride inhibitor of serine peptidases.
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DOI: 10.1039/d3dt00458a
Abstract: Peptidases are regulated by latency and inhibitors, as well as compatibilization and cofactors. Ulilysin from Methanosarcina acetivorans, also called lysargiNase, is an archaeal metallopeptidase (MP) that is biosynthesized as a zymogen with a 60-residue N-terminal… read more here.
Keywords: lysarginase; metallopeptidase; inhibitor; sulfonyl fluoride ... See more keywords
Leishmania donovani Inhibitor of Serine Peptidases 2 Mediated Inhibition of Lectin Pathway and Upregulation of C5aR Signaling Promote Parasite Survival inside Host
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DOI: 10.3389/fimmu.2018.00063
Abstract: Leishmania donovani, the causative agent of Indian visceral leishmaniasis has to face several barriers of the immune system inside the mammalian host for its survival. The complement system is one of the first barriers and… read more here.
Keywords: serine; host; donovani; serine peptidases ... See more keywords