Identification of two subtilisin‐like serine proteases engaged in the degradation of recombinant proteins in Nicotiana benthamiana
Sign Up to like & getrecommendations! Published in 2020 at "Febs Letters"
DOI: 10.1002/1873-3468.14014
Abstract: The tobacco variant Nicotiana benthamiana has recently emerged as a versatile host for the manufacturing of protein therapeutics, but the fidelity of many recombinant proteins generated in this system is compromised by inadvertent proteolysis. Previous… read more here.
Keywords: serine proteases; subtilisin like; like serine; recombinant proteins ... See more keywords
Tagged Benzoxazin‐4‐Ones as Novel Activity‐Based Probes for Serine Proteases
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202000848
Abstract: Activity‐based probes (ABPs) are valuable chemical tools for profiling enzymes. They have been particularly useful in the study of proteases. ABPs rely on electrophilic scaffolds that covalently modify the target enzymes. Ideally, they can be… read more here.
Keywords: serine proteases; tagged benzoxazin; benzoxazin ones; activity based ... See more keywords
Serine proteases in neutrophil extracellular traps exhibit anti-Respiratory Syncytial Virus activity.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108573
Abstract: Human respiratory syncytial virus (hRSV) is an infectious agent in infants and young children which there are no vaccines or drugs for treatment. Neutrophils are recruited for airway, where they are stimulated by hRSV to… read more here.
Keywords: serine proteases; respiratory syncytial; neutrophil extracellular; extracellular traps ... See more keywords
Citrus bioflavonoid, hesperetin, as inhibitor of two thrombin‐like snake venom serine proteases isolated from Crotalus simus
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DOI: 10.1016/j.toxicon.2018.01.005
Abstract: ABSTRACT Around 5.5 million people suffer from snakebites per year, with about 400,000 cases with some type of sequelae, such as amputation, and 20,000 to 125,000 cases with the fatal end. Usually, the victim outcome… read more here.
Keywords: thrombin like; serine proteases; inhibitor; crotalus simus ... See more keywords
Coevolved Positions Represent Key Functional Properties in the Trypsin-Like Serine Proteases Protein Family
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00903
Abstract: Trypsin-like Serine Proteases are a group of homologous enzymes which exert multiple roles in both vertebrate and invertebrate organisms. Key properties of these enzymes include their activation from an inactive zymogen form to their active… read more here.
Keywords: trypsin like; like serine; serine proteases; protein family ... See more keywords
Activity-based probes for the high temperature requirement A serine proteases.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00279
Abstract: The high temperature requirement A (HTRA) family of serine proteases mediates protein quality control. These proteins process misfolded proteins in several diseases including Alzheimer's disease (AD) and Parkinson's disease (PD). While their structures and activation… read more here.
Keywords: serine proteases; based probes; high temperature; activity based ... See more keywords
The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation
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DOI: 10.1038/s41467-021-26495-2
Abstract: Despite recent advances in understanding skin scarring, mechanisms triggering hypertrophic scar formation are still poorly understood. In the present study, we investigate mature human hypertrophic scars and developing scars in mice at single cell resolution.… read more here.
Keywords: dipeptidyl peptidase; scar; serine proteases; scar formation ... See more keywords
Human primary endothelial label-free biochip assay reveals unpredicted functions of plasma serine proteases
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DOI: 10.1038/s41598-020-60158-4
Abstract: Tissue-on-a-chip technologies are more and more important in the investigation of cellular function and in the development of novel drugs by allowing the direct screening of substances on human cells. Constituting the inner lining of… read more here.
Keywords: serine proteases; plasma serine; free biochip; label free ... See more keywords
SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress
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DOI: 10.1038/s41598-020-78402-2
Abstract: The COVID-19 pandemic resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged in December 2019 in Wuhan in China has placed immense burden on national economies and global health. At present neither… read more here.
Keywords: serine proteases; serine; cellular stress; transmembrane serine ... See more keywords
Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin.
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DOI: 10.1039/c9md00234k
Abstract: Matriptase and hepsin are type II transmembrane serine proteases (TTSPs). Along with related S1 trypsin like serine protease HGFA (hepatocyte growth factor activator), their unregulated proteolytic activity has been associated with cancer including tumor progression… read more here.
Keywords: serine proteases; piperidine carbamate; matriptase hepsin;
Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteases
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201423119
Abstract: Significance Ovarian cancer is the most lethal gynecological cancer. Clinically approved chemotherapies aim to slow or stop tumor growth; however, cancer cells continue to evolve between chemotherapy cycles, acquiring properties that allow cell survival and… read more here.
Keywords: metastatic ovarian; ovarian cancer; anchored serine; membrane anchored ... See more keywords