Serine Racemase Expression by Striatal Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00880-9
Abstract: d -serine is synthesized by serine racemase (SR) and is a co-agonist at forebrain N -methyl- d -aspartate receptors (NMDARs). d -serine and SR are expressed primarily in neurons, but not in quiescent astrocytes. In… read more here.
Keywords: serine racemase; serine; expression; mice ... See more keywords
Deletion of serine racemase confers D-serine –dependent resilience to chronic social defeat stress
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2018.03.008
Abstract: ABSTRACT The N‐methyl‐D‐aspartate receptor (NMDAR) plays a key role in the pathophysiology of depression. Serine racemase (SRR, encoded by Srr) converts L‐serine to D‐serine, an endogenous co‐agonist at the glycine site of the NMDAR. Knock‐out… read more here.
Keywords: depression; serine racemase; serine; resilience ... See more keywords
Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.10.055
Abstract: D-Serine, an endogenous coagonist of N-methyl-d-aspartate receptors (NMDARs) at the glycine binding site, is synthesized by serine racemase (SR) through conversion of l-Serine. Dysregulation of SR/D-Serine and Disrupted-In-Schizophrenia-1 (DISC1) contributes to the pathogenesis of schizophrenia… read more here.
Keywords: serine racemase; serine; disc1 agglomerates; schizophrenia disc1 ... See more keywords
Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Sign Up to like & getrecommendations! Published in 2022 at "Communications biology"
DOI: 10.1038/s42003-022-03264-5
Abstract: Human serine racemase (hSR) catalyses racemisation of L-serine to D-serine, the latter of which is a co-agonist of the NMDA subtype of glutamate receptors that are important in synaptic plasticity, learning and memory. In a… read more here.
Keywords: pocket; core small; ligandable pocket; serine ... See more keywords
Commentary on "Urinary L-erythro-β-hydroxyasparagine - a novel serine racemase inhibitor and substrate of the Zn2+-dependent D-serine dehydratase".
Sign Up to like & getrecommendations! Published in 2021 at "Bioscience reports"
DOI: 10.1042/bsr20211524
Abstract: The analysis of the urine contents can be informative of physiological homeostasis, and it has been speculated that the levels of urinary D-serine (D-ser) could inform about neurological and renal disorders. By analysing the levels… read more here.
Keywords: commentary urinary; dehydratase; ser; racemase ... See more keywords
Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid‐β oligomers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15664
Abstract: Dysregulation of insulin signaling in the Alzheimer's disease (AD) brain has been extensively reported. Serine racemase (SR) modulates insulin secretion in pancreatic islets. This study aimed to examine whether SR regulates insulin synthesis and secretion… read more here.
Keywords: serine racemase; srr neurons; secretion; insulin signaling ... See more keywords
Serine racemase expression differentiates aging from Alzheimer's brain.
Sign Up to like & getrecommendations! Published in 2022 at "Current Alzheimer research"
DOI: 10.2174/1567205019666220805105106
Abstract: Aging is an inevitable process characterized with progressive loss of physiological integrity and increased susceptibility to cancer, diabetes, cardiovascular, and neurodegenerative diseases; regarding the last, aging is the primary risk factor for Alzheimer's disease (AD),… read more here.
Keywords: racemase expression; aging brain; brain; serine racemase ... See more keywords
The Energy Landscape of Human Serine Racemase
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2018.00112
Abstract: Human serine racemase is a pyridoxal 5′-phosphate (PLP)-dependent dimeric enzyme that catalyzes the reversible racemization of L-serine and D-serine and their dehydration to pyruvate and ammonia. As D-serine is the co-agonist of the N-methyl-D-aspartate receptors… read more here.
Keywords: human serine; energy landscape; serine racemase; racemase ... See more keywords