NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.09.010
Abstract: Nuclear factor erythroid-2 related factor 2 (NRF2) is a pivotal transcription factor; that maintains cellular redox homeostasis and facilitates the development of; malignant tumor phenotypes. At the molecular level, NRF2 promotes de novo serine; synthesis… read more here.
Keywords: sumoylation; tumorigenesis; serine synthesis; nrf2 sumoylation ... See more keywords
3-Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo l-Serine Synthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00990
Abstract: The enzymatic mechanism of 3-phosphoglycerate to 3-phosphohydroxypyruvate oxidation, which forms the first step of the main conserved de novo serine synthesis pathway, has been revisited recently in certain microorganisms. While this step is classically considered… read more here.
Keywords: phosphoglycerate; serine synthesis; yeast; novo serine ... See more keywords
Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01749-x
Abstract: Cancer cells undergo metabolic adaption to sustain their survival and growth under metabolic stress conditions, yet the underlying mechanism remains largely unclear. It is also not known if lncRNAs contribute to this metabolic adaption of… read more here.
Keywords: synthesis pathway; hepatocellular carcinogenesis; cancer; serine synthesis ... See more keywords
Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment?
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00474-4
Abstract: To sustain their malignancy, tumour cells acquire several metabolic adaptations such as increased oxygen, glucose, glutamine, and lipids uptake. Other metabolic processes are also enhanced as part of tumour metabolic reprogramming, for example, increased serine… read more here.
Keywords: serine synthesis; small molecular; novo serine; cancer ... See more keywords
TMET-65. SETD2 Loss Predicts Favorable Prognosis in Glioblastoma via Suppression of the Serine Synthesis Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1756
Abstract: Glioblastoma (GBM) is an aggressive primary brain tumor characterized by poor prognosis and limited treatment options. SETD2, a histone H3K36 trimethyltransferase, maintains genomic integrity and regulates transcriptional and metabolic processes. Although SETD2 loss has been… read more here.
Keywords: synthesis pathway; loss; prognosis; serine synthesis ... See more keywords
Loss of USP10 promotes hepatocellular carcinoma proliferation by regulating the serine synthesis pathway through inhibition of LKB1 activity
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Science"
DOI: 10.1111/cas.16336
Abstract: Metabolic dysregulation is emerging as a critical factor in tumorigenesis, and reprogramming of serine metabolism has been identified as an essential factor in the progression of hepatocellular carcinoma (HCC). Studies have shown that LKB1 deficiency… read more here.
Keywords: hcc; hepatocellular carcinoma; serine synthesis; proliferation ... See more keywords
Abstract 4173: Compensatory interactions between tryptophan catabolism and serine metabolism highlight potential vulnerabilities in TNBC cells with dysregulated de novo serine synthesis
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4173
Abstract: Despite the major advances people have achieved in treating breast cancer, triple-negative breast cancer (TNBC) remains a difficult cancer to conquer. TNBC is one of the most heterogeneous and aggressive forms of breast cancer and… read more here.
Keywords: tryptophan catabolism; novo serine; metabolism; synthesis ... See more keywords
Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.7554/elife.104423
Abstract: The differentiation and suppressive functions of regulatory CD4 T cells (Tregs) are supported by a broad array of metabolic changes, providing potential therapeutic targets for immune modulation. In this study, we focused on the regulatory… read more here.
Keywords: differentiation; one carbon; pgam; carbon metabolism ... See more keywords