Changing rate of serious infections in biologic-exposed rheumatoid arthritis patients. Data from South American registries BIOBADABRASIL and BIOBADASAR
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Rheumatology"
DOI: 10.1007/s10067-019-04516-2
Abstract: ObjectiveMost reports on serious infections (SI) in rheumatoid arthritis (RA) patients treated with biological disease-modifying antirheumatic drugs (bDMARDs) are from the USA and Western Europe. Data from other regions are largely missing. We report data… read more here.
Keywords: data south; patients treated; arthritis patients; south american ... See more keywords
Adult-onset inflammatory bowel disease and rate of serious infections compared to the general population: a nationwide register-based cohort study 2002–2017
Sign Up to like & getrecommendations! Published in 2021 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2021.1924259
Abstract: Abstract Objectives To investigate absolute and relative risk of serious infections in adult/elderly inflammatory bowel disease (IBD) diagnosed 2002–2017. Methods Nationwide, register-based cohort study of Swedish patients with IBD compared with general population matched reference… read more here.
Keywords: bowel disease; inflammatory bowel; disease; serious infections ... See more keywords
The Risk of Serious Infections Before and After Anti-TNF Therapy in Inflammatory Bowel Disease: A Retrospective Cohort Study
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DOI: 10.1093/ibd/izac097
Abstract: Abstract Background Serious infections have been observed in patients with inflammatory bowel disease (IBD) on anti-TNF use—but to what extent these infections are due to anti-TNF or the disease activity per se is hard to… read more here.
Keywords: anti tnf; tnf therapy; disease; inflammatory bowel ... See more keywords
Serious Infections in Offspring Exposed in Utero to Vedolizumab.
Sign Up to like & getrecommendations! Published in 2023 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izad079
Abstract: Controlling IBD during pregnancy is important for maternal and fetal outcomes. We created a cohort of children born to mothers with IBD, comparing the risk of infections in those exposed to vedolizumab vs unexposed. We… read more here.
Keywords: utero vedolizumab; infections offspring; offspring exposed; serious infections ... See more keywords
Glucocorticoid exposure and the risk of serious infections in rheumatoid arthritis-a marginal structural model application.
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead083
Abstract: OBJECTIVE Observational studies have reported an increased risk of infections associated with glucocorticoids in rheumatoid arthritis (RA), not supported by evidence from randomized controlled trials. Inappropriately accommodating time-varying exposure and confounding in observational studies might… read more here.
Keywords: rheumatology; rheumatoid arthritis; risk; marginal structural ... See more keywords
Using epidemiological methods to quantify the risk of serious infections in children with atopic dermatitis
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Dermatology"
DOI: 10.1111/bjd.20395
Abstract: In their article in this issue, Droitcourt et al. investigate the risk of some systemic infections leading to hospitalization in children with atopic dermatitis (AD) compared with sexand age-matched comparators in Denmark. Studied outcomes were… read more here.
Keywords: risk; infection; atopic dermatitis; serious infections ... See more keywords
Infection risk with carfilzomib in multiple myeloma: a systematic review and meta‐analysis of randomised controlled trials
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DOI: 10.1111/bjh.16735
Abstract: Carfilzomib is an irreversible epoxyketone-based proteasome inhibitor (PI) that is specific for the chymotrypsin-like active site of 20S proteasome. In 2012, carfilzomib was first approved for the treatment of relapsed/refractory multiple myeloma (MM). It has… read more here.
Keywords: risk; analysis; infection; serious infections ... See more keywords
Assessment of serious infections in pemphigus and pemphigoid by a national registry
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DOI: 10.1111/jdv.15237
Abstract: Autoimmune blistering dermatosis (AIBD) are potentially lethal, chronic relapsing disorders affecting the skin and mucous membranes which are mainly associated with IgG autoantibodies against distinct adhesion proteins of the epidermis or basement membrane zone (BMZ).… read more here.
Keywords: aibd; risk; pemphigus pemphigoid; infections pemphigus ... See more keywords
Nanopore-Targeted Sequencing Improves the Diagnosis and Treatment of Patients with Serious Infections
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DOI: 10.1128/mbio.03055-22
Abstract: We introduce the application of NTS in blood samples of patients with serious infections and expound the efficiency and accuracy of NTS in detecting pathogenic microorganisms. Our work builds on the considerable interest of the… read more here.
Keywords: diagnosis; infection; patients serious; blood ... See more keywords
OP0225 SERIOUS INFECTIONS IN OFFSPRING EXPOSED IN UTERO TO NON-TNFI BIOLOGICS AND TOFACITINIB
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.5900
Abstract: Background During pregnancy, maternal circulating immunoglobulins G (IgG) are actively transported across the placenta through their Fc portion. Thus, TNFi and other biologics harbouring an Fc part have the potential to transfer across the placenta,… read more here.
Keywords: tnfi; non tnfi; tnfi biologics; biologics tofacitinib ... See more keywords
AB0626 INCIDENCE OF SERIOUS INFECTIONS AND PATTERNS OF COTRIMOXAZOLE PROPHYLAXIS IN PATIENTSWITH ANCA-ASSOCIATED VASCULITIDES
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.7243
Abstract: Background: Infections are among the most serious complications in patients with aNCA-associated vasculitides (AAV) and contribute significantly in overall mortality. Objectives: To describe the incidence and risk factors for serious infections, as well as the… read more here.
Keywords: incidence; associated vasculitides; cotrimoxazole prophylaxis; serious infections ... See more keywords